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Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

Project Summary Metabolic reprogramming plays a critical role in carcinogenesisin part due its ability to promote immune suppressive properties within tumorsHoweverit is unclear whether inhibition of fatty acid metabolism in tumors affects their immunogenicityHerewe show for the first time that inhibition of stearoyl CoA desaturaseSCDthe rate limiting enzyme involved in fatty acid synthesis conver ...

Project SummaryAbstractThis proposal presents Phase II of Mercury Biomedandapos s plan for commercializing the new and innovative WarmSmart technology to more effectively keep surgical patients normothermicWarmSmart embodies several breakthrough concepts in bioheat transfer to manage core temperatureWe are building a costcompetitive patient warming technology that will be superior to existing tech ...

Optonicus proposes development of the Wide-Area Laser Additive Manufacturing in Metals with Adaptive Beam Shaping (WALAM-ABS) laser additive manufacturing (LAM) system. The WALAM-ABS metal additive manufacturing system will solve long-standing drawbacks imposed by current single-point selective laser melting LAM technology through the use of wide-area processing based on proprietary multi-beam fib ...

Augmented reality (AR) offers the ability to enhance existing combat medic training by including perceptual cues and adaptive training elements to traditional simulation-based training using manikins. Unveil has developed a training system called the Macrocognitive AR Trainer (MART). MART is designed to foster the development of macrocognitive skills (e.g., sensemaking, assessment skills, mental m ...

Presently the missile defense systems are using a reactive and program-centric framework for assessing industrial base risk. The Phase I effort focused on developing a wide and deep network algorithm using Industrial Product-Support Vendor (IPV) Gen II program for predicting the probability of failure. The proposed Phase II effort leverages the Phase I work and will focus on three main goals:(1) I ...

Autism spectrum disorderASDis a neurodevelopmental disorder characterized by significant deficits in reciprocal social interactionsimpaired communication and restrictedrepetitive behaviorswith a prevalence ofinchildren in the USEarly intervention programs have been shown to be effective for improving IQlanguageand social skills for toddlers as young asmonths of ageDiagnosis of ASD is currently bas ...

This Phase-II STTR research effort is designed to forward the engineering investigation of the dynamics and control of turbulent combustion in high-pressure combustion systems by developing a set of game-changing nonlinear analysis tools that can significantly improve the post-processing speed and intelligent data mining of large numerical or experimental data sets. Moreover, a system based on non ...

The Army is frequently forced to operate in hostile climates. Heavy fog, rain, snow, and dust storms can inhibit the performance of tracking technologies such as mid-wave infrared cameras. In such conditions, Army early warning systems are blinded and put personnel and assets at risk.There is a specific need for a degraded visual environment (DVE) penetrative target tracking solution.Radio frequen ...

The overall goal of the proposed research program is to develop a ruggedized imaging system capable of visualization and analysis of the particle field and product gases in a multiphase blast. This will be accomplished by combining kHz-MHz-rate burst-mode laser technology with tomographic particle field velocimetry (PFV) and new nonlinear particle tracking methods to resolve dense particle fields. ...