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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Development of a small molecule activator of integrin cell adhesion to enhance therapeutic responses to checkpoint blockade in cancer

    SBC: 7 Hills Pharma LLC            Topic: 102

    Recent FDA approvals of ipilimumabnivolumaband pembrolizumabwhich target checkpoint receptors cytotoxic T lymphocyte associated antigenCTLAand programmed deathPDhave ushered in a new era of cancer immunotherapy in metastatic melanomaDespite unprecedented overall survival benefits with combination therapythe incidence of complete responses are onlyimmune related adverse eventsirAEsare increasedand ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Proteasome inhibitor re-sensitizing molecules for treatment of refractory multiple myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: 102

    Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Novel SCD1 inhibitors for treatment of cancer

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    Project Summary Metabolic reprogramming plays a critical role in carcinogenesisin part due its ability to promote immune suppressive properties within tumorsHoweverit is unclear whether inhibition of fatty acid metabolism in tumors affects their immunogenicityHerewe show for the first time that inhibition of stearoyl CoA desaturaseSCDthe rate limiting enzyme involved in fatty acid synthesis conver ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Developing an automated yeast dissection system for aging research

    SBC: Innovative BioChips LLC            Topic: NIA

    PROJECT SUMMARY Developing an Automated Yeast Dissection System for Aging ResearchAging is the single greatest risk factor for diseases that are principal causes of mortalityThe objectives of aging research are to discover key genes and pathways related to aging that may eventually contribute to retardation of aging and a delay in the onset of age associated diseasesThe budding yeast Saccharomyces ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Monolithic Slow Light Enhanced Chip-Integrated Absorption Spectrometer from 3-15 microns

    SBC: Omega Optics, Inc.            Topic: A17AT005

    We will develop a lab-on-chip optical absorption spectrometer spanning 3-15micron molecular fingerprint region, in a single epitaxially grown heterostructure that monolithically integrates thermally tuned distributed feedback quantum cascade laser (QCL) and quantum cascade detector (QCD) arrays with slotted photonic crystal waveguides (SPCWs) in a mid-infrared InGaAs passive photonic waveguide. In ...

    STTR Phase II 2018 Department of DefenseArmy
  6. Multiple Antenna Element Approach to a Combined Precision Attitude Determination and GPS Anti-Jamming/Spoofing Capability

    SBC: UHU TECHNOLOGIES LLC            Topic: A15AT013

    A multichannel GPS system, with associated Controlled Radiation Pattern Antenna Array (CRPA) design, will provide continuous position and attitude determination. This system supports L1/L2 and SAASM or M-Code modes under both GPS jamming, and spoofing attack, to maintain navigation and attitude in contested environments. The system uses direction finding to determine angle of arrival (AOA for the ...

    STTR Phase II 2018 Department of DefenseArmy
  7. Non-invasive Telemetric Assessment of Gut Microbiota Activity in Situ

    SBC: NANOHMICS INC            Topic: DHP17A004

    Different regions of the human GI tract exhibit different chemical environments and different digestion metabolites. As a result, these regions support different microorganisms, with gradients in metabolic products along the length of the GI tract. Single-point measurements of microbiome metabolites (e.g. in feces) are insufficient to provide detailed information of physiological status because th ...

    STTR Phase II 2018 Department of DefenseDefense Health Program
  8. EMS Monitor & Broadcast Training Capacity Enhancement

    SBC: Kerberos International, Inc.            Topic: A15AT008

    Americas current electronic warfare (EW) capabilities are insufficient for the modern and future battlefield. To safeguard against radio-controlled threats and disrupt enemy communications, our current EW systems blindly jam broad swaths of the electromagnetic spectrum (EMS). This approach interferes with Blue Force data and voice communications, requires large power sources and generates distinct ...

    STTR Phase II 2018 Department of DefenseArmy
  9. Medical Device to Assess the Viability of Tissue Prior to Skin Grafting

    SBC: Spectral Md, Inc.            Topic: DHP17A006

    The primary objective of this Phase II proposal is to construct and validate the portable SpectralMD DeepView imaging technology designed previously in Phase I. This device allows surgeons to quickly and objectively assess tissue viability in burn surgery prior to skin grafting. DeepView uses machine learning and multispectral imaging to generate quantitative prognostic images with easily interpre ...

    STTR Phase II 2018 Department of DefenseDefense Health Program
  10. Methodologies for Cost-Effective Measurement of Dynamic Material Properties or Characterization of Materials under Dynamic Loads

    SBC: PROTECTION ENGINEERING CONSULTANTS LLC            Topic: MDA16T003

    Explosions and high-velocity impacts can create strain rates on the order of 105 to 107 s-1.To simulate these events, first-principles codes require material models that are valid at these loading rates.Currently, the amount of test data, material models and material constants for this strain rate range is extremely limited, and an innovative and cost-effective laboratory test procedure is needed. ...

    STTR Phase II 2018 Department of DefenseMissile Defense Agency
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