Award Data

Recent FDA approvals of ipilimumabnivolumaband pembrolizumabwhich target checkpoint receptors cytotoxic T lymphocyte associated antigenCTLAand programmed deathPDhave ushered in a new era of cancer immunotherapy in metastatic melanomaDespite unprecedented overall survival benefits with combination therapythe incidence of complete responses are onlyimmune related adverse eventsirAEsare increasedand ...

Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

Project Summary Metabolic reprogramming plays a critical role in carcinogenesisin part due its ability to promote immune suppressive properties within tumorsHoweverit is unclear whether inhibition of fatty acid metabolism in tumors affects their immunogenicityHerewe show for the first time that inhibition of stearoyl CoA desaturaseSCDthe rate limiting enzyme involved in fatty acid synthesis conver ...

PROJECT SUMMARY Developing an Automated Yeast Dissection System for Aging ResearchAging is the single greatest risk factor for diseases that are principal causes of mortalityThe objectives of aging research are to discover key genes and pathways related to aging that may eventually contribute to retardation of aging and a delay in the onset of age associated diseasesThe budding yeast Saccharomyces ...

Composites Automation LLC (CA), our academic partner University of Delaware – Center for Composite Materials (UD-CCM) are teaming up in this STTR Phase II project to evaluate automated tape placement (ATP) processing of thin-ply composites, including material and process development, creation of a modeling foundation capturing thin-ply placement, test panel fabrication and mechanical performance ...

There is a disconnect between the mission operation languages used by various NASA robots and by flight controllers or crew members. This disconnect unduly burdens mission operators, as it requires the involvement of expert robot programmers to define each activity. To eliminate this burden, we propose that robots in space (whether autonomous or remotely commanded by humans) should be commanded us ...

DESCRIPTION (provided by applicant): This proposal is the Phase II renewal of an STTR award to Kardia Therapeutics undertaken in collaboration with Baylor College of Medicine (the home to Kardia's founding scientists). The project will accelerate the development and commercialization of human heart-derived cardiac progenitor cells (CPCs), to promote more effective regenerative growth in human hear ...

DESCRIPTION (provided by applicant): Expanding use of microarray systems for global gene expression profiling is leading biological research, providing diagnostic and prognostic value to physicians and facilitating target discovery during drug and vaccine development. There is strong interest in extending this microarray capability to more RNA-limited material to the point that a single cell can b ...

In completing the Phase I SBIR, Agave BioSystems and the Universities Space Research Association, have successfully demonstrated proof of concept for the use of novel carbon nanotube (CNT)-based structures as next generation smart adsorbents for the adsorption and destruction of potentially toxic air contaminants. Since CNTs have an extremely high surface area, can be readily modified with metals ...

The Integrated Data Assimilation Architecture (IDAA) addresses the fundamental problem of command, control, and communications systems interoperability. Interoperability of Explorations systems is necessary to improve reliability, reduce complexity, increase software and hardware reusability, and enable multi-developer / multi-agency support. The IDAA architecture consists of a software component ...