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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Development of a small molecule activator of integrin cell adhesion to enhance therapeutic responses to checkpoint blockade in cancer

    SBC: 7 Hills Pharma LLC            Topic: 102

    Recent FDA approvals of ipilimumabnivolumaband pembrolizumabwhich target checkpoint receptors cytotoxic T lymphocyte associated antigenCTLAand programmed deathPDhave ushered in a new era of cancer immunotherapy in metastatic melanomaDespite unprecedented overall survival benefits with combination therapythe incidence of complete responses are onlyimmune related adverse eventsirAEsare increasedand ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Proteasome inhibitor re-sensitizing molecules for treatment of refractory multiple myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: 102

    Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Novel SCD1 inhibitors for treatment of cancer

    SBC: MODULATION THERAPEUTICS, INC.            Topic: 102

    Project Summary Metabolic reprogramming plays a critical role in carcinogenesisin part due its ability to promote immune suppressive properties within tumorsHoweverit is unclear whether inhibition of fatty acid metabolism in tumors affects their immunogenicityHerewe show for the first time that inhibition of stearoyl CoA desaturaseSCDthe rate limiting enzyme involved in fatty acid synthesis conver ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Developing an automated yeast dissection system for aging research

    SBC: Innovative BioChips LLC            Topic: NIA

    PROJECT SUMMARY Developing an Automated Yeast Dissection System for Aging ResearchAging is the single greatest risk factor for diseases that are principal causes of mortalityThe objectives of aging research are to discover key genes and pathways related to aging that may eventually contribute to retardation of aging and a delay in the onset of age associated diseasesThe budding yeast Saccharomyces ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Monolithic Slow Light Enhanced Chip-Integrated Absorption Spectrometer from 3-15 microns

    SBC: Omega Optics, Inc.            Topic: A17AT005

    We will develop a lab-on-chip optical absorption spectrometer spanning 3-15micron molecular fingerprint region, in a single epitaxially grown heterostructure that monolithically integrates thermally tuned distributed feedback quantum cascade laser (QCL) and quantum cascade detector (QCD) arrays with slotted photonic crystal waveguides (SPCWs) in a mid-infrared InGaAs passive photonic waveguide. In ...

    STTR Phase II 2018 Department of DefenseArmy
  6. Multiple Antenna Element Approach to a Combined Precision Attitude Determination and GPS Anti-Jamming/Spoofing Capability

    SBC: UHU TECHNOLOGIES LLC            Topic: A15AT013

    A multichannel GPS system, with associated Controlled Radiation Pattern Antenna Array (CRPA) design, will provide continuous position and attitude determination. This system supports L1/L2 and SAASM or M-Code modes under both GPS jamming, and spoofing attack, to maintain navigation and attitude in contested environments. The system uses direction finding to determine angle of arrival (AOA for the ...

    STTR Phase II 2018 Department of DefenseArmy
  7. EMS Monitor & Broadcast Training Capacity Enhancement

    SBC: Kerberos International, Inc.            Topic: A15AT008

    Americas current electronic warfare (EW) capabilities are insufficient for the modern and future battlefield. To safeguard against radio-controlled threats and disrupt enemy communications, our current EW systems blindly jam broad swaths of the electromagnetic spectrum (EMS). This approach interferes with Blue Force data and voice communications, requires large power sources and generates distinct ...

    STTR Phase II 2018 Department of DefenseArmy
  8. Monolithic photonic platform for high-power InGaAs/AlInAs quantum cascade laser beam combining and steering

    SBC: TransWave Photonics, LLC            Topic: A17AT006

    TransWave Photonics, LLC proposes to develop mid-wave infrared photonic integrated circuits based on monolithic integration of passive low-loss waveguides, thermo-optically tunable photonic elements, and quantum cascade gain sections within the same InGaAs/AlInAs/InP platform. The proposed approach will enable power combining and 2-dimensinoal beam steering of the outputs from multiple high-power ...

    STTR Phase II 2018 Department of DefenseArmy
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