Award Data

Recent FDA approvals of ipilimumabnivolumaband pembrolizumabwhich target checkpoint receptors cytotoxic T lymphocyte associated antigenCTLAand programmed deathPDhave ushered in a new era of cancer immunotherapy in metastatic melanomaDespite unprecedented overall survival benefits with combination therapythe incidence of complete responses are onlyimmune related adverse eventsirAEsare increasedand ...

Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

Project Summary Metabolic reprogramming plays a critical role in carcinogenesisin part due its ability to promote immune suppressive properties within tumorsHoweverit is unclear whether inhibition of fatty acid metabolism in tumors affects their immunogenicityHerewe show for the first time that inhibition of stearoyl CoA desaturaseSCDthe rate limiting enzyme involved in fatty acid synthesis conver ...

DESCRIPTION provided by applicant Intracerebral hemorrhage ICH is a major public health problem with the highest mortality rate of all stroke subtypes ICH is one of the leading causes of long term disability Since there are no available FDA approved therapies for ICH it is of vast importance to search for new approaches in treatment for this devastating medical condition Lactoferrin LT ...

PROJECT SUMMARY Developing an Automated Yeast Dissection System for Aging ResearchAging is the single greatest risk factor for diseases that are principal causes of mortalityThe objectives of aging research are to discover key genes and pathways related to aging that may eventually contribute to retardation of aging and a delay in the onset of age associated diseasesThe budding yeast Saccharomyces ...

DESCRIPTION provided by applicant This proposal is for a phase I II fast track project for the STTR program with the main goal to develop a blood test for Alzheimerandapos s disease AD diagnosis AD is the most common dementia in the elderly population and one of the leading causes of death in the developed world One of the main problems in AD is the lack of an early sensitive and objective ...

We will develop a lab-on-chip optical absorption spectrometer spanning 3-15micron molecular fingerprint region, in a single epitaxially grown heterostructure that monolithically integrates thermally tuned distributed feedback quantum cascade laser (QCL) and quantum cascade detector (QCD) arrays with slotted photonic crystal waveguides (SPCWs) in a mid-infrared InGaAs passive photonic waveguide. In ...

A multichannel GPS system, with associated Controlled Radiation Pattern Antenna Array (CRPA) design, will provide continuous position and attitude determination. This system supports L1/L2 and SAASM or M-Code modes under both GPS jamming, and spoofing attack, to maintain navigation and attitude in contested environments. The system uses direction finding to determine angle of arrival (AOA for the ...

Americas current electronic warfare (EW) capabilities are insufficient for the modern and future battlefield. To safeguard against radio-controlled threats and disrupt enemy communications, our current EW systems blindly jam broad swaths of the electromagnetic spectrum (EMS). This approach interferes with Blue Force data and voice communications, requires large power sources and generates distinct ...

In Phase I, TRI/Austin teamed with Missouri S&T to investigate and refine several technologies, i.e. synthetic aperture radar (SAR) imaging algorithms; advanced Compressive Sensing (CS) techniques; innovative imaging hardware; under-sampling; etc, as they apply to high speed millimeter wave imaging. These investigations were supported by both modeling and empirical testing. The Phase I results c ...