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Project SummaryAbstract The neurofibromatosesNFsincluding NFNFand schwannomatosisare a group of autosomal dominant neurogenetic disorders characterized by a predisposition in virtuallyof patients to develop multiple nerve sheath tumorsThe determination of tumor burden on magnetic resonance imagingMRIis indispensable for the longitudinal management of NF patientswhich includes life long follow up f ...

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Rodents serve as models for the human brain and behavior, and their calls give researchers a window into their mood. Unfortunately, rodent calls are ultrasonic, so a researcher must record a test and then play the audio back at a slower speed to manually categorize and count calls. Software does exist to accomplish this task, but it does not have the ease of use or accuracy that researchers want. ...

Accurate assessment of burn depth and surface area are important to clinical decision-making regarding treatment. Initial assessment determines fluid requirements and transportation decisions to distant-care facilities. The clinician must determine if the wound will heal itself or whether excision and grafting are necessary for optimal wound healing. The standard of care remains visual inspection ...

Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

There are several current and imminent orthotic and prosthetic (O&P) fitting scenarios that would greatly benefit from the ability to wirelessly collect and transmit physiological information from the user. Both upper- and lower- limb O&P fittings that: 1) use osseointegration, 2) have cable management issues, and 3) could benefit from physiological information from locations proximal to the prost ...

It is generally recognized that the human body transmits electro-magnetic fields (EMF). The Phase I program demonstrated a practical solution to detect these emissions. The technology was shown to be compatible for integration into wearable textiles. The Phase 2 program will focus on demonstrating the capability of discriminating between healthy and injury related EMF emissions such that it can be ...

Project SummaryAbstract Tumor imaging quantification is critical for diagnosisstagingand treatment evaluationand multi detector CTMDCTis the clinical imaging modality commonly used for patients diagnosed with hepatic malignancy because of its relatively low cost and wide availabilityConventional tumor quantification using either linear or volumetric measurement has demonstrated significant limitat ...

Airway compromise is the third leading cause of potentially preventable death on the battlefield. Current evaluation techniques of the airways associated with smoke inhalation injury are highly subjective and lack the sensitivity required of an accurate diagnostic and assessment tool. The problem of detection is further compounded by the late onset of symptoms that in many cases do not present unt ...