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Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

Recent FDA approvals of ipilimumabnivolumaband pembrolizumabwhich target checkpoint receptors cytotoxic T lymphocyte associated antigenCTLAand programmed deathPDhave ushered in a new era of cancer immunotherapy in metastatic melanomaDespite unprecedented overall survival benefits with combination therapythe incidence of complete responses are onlyimmune related adverse eventsirAEsare increasedand ...

Despite the myriad major advances in cardiologythe prognosis for patients with severemedically refractive heart failureHFis exceedingly poorApproximatelydeaths occur annually in patients with HF who have endured an impaired quality of life often accompanied by significant economic and personal losses due to recurrent hospitalizationsAt leastof these deaths were directly related to severe heart fai ...

PROJECT SUMMARY There is need for an artificial oxygenOcarrier to substitute for banked blood in settings wherestored blood is unavailablepre hospital care transportaustere environmentsundeveloped countriesorundesirabletransfusion risk exceeds benefitTo address this needwe developedErythroMerEMa first inclass nano cyte blood substituteEM is a deformablecross linked polymeric nanoparticle that inco ...

PROJECT SUMMARY Developing an Automated Yeast Dissection System for Aging ResearchAging is the single greatest risk factor for diseases that are principal causes of mortalityThe objectives of aging research are to discover key genes and pathways related to aging that may eventually contribute to retardation of aging and a delay in the onset of age associated diseasesThe budding yeast Saccharomyces ...

TransWave Photonics, LLC proposes to develop mid-wave infrared photonic integrated circuits based on monolithic integration of passive low-loss waveguides, thermo-optically tunable photonic elements, and quantum cascade gain sections within the same InGaAs/AlInAs/InP platform. The proposed approach will enable power combining and 2-dimensinoal beam steering of the outputs from multiple high-power ...

We will develop a lab-on-chip optical absorption spectrometer spanning 3-15micron molecular fingerprint region, in a single epitaxially grown heterostructure that monolithically integrates thermally tuned distributed feedback quantum cascade laser (QCL) and quantum cascade detector (QCD) arrays with slotted photonic crystal waveguides (SPCWs) in a mid-infrared InGaAs passive photonic waveguide. In ...

A multichannel GPS system, with associated Controlled Radiation Pattern Antenna Array (CRPA) design, will provide continuous position and attitude determination. This system supports L1/L2 and SAASM or M-Code modes under both GPS jamming, and spoofing attack, to maintain navigation and attitude in contested environments. The system uses direction finding to determine angle of arrival (AOA for the ...

Americas current electronic warfare (EW) capabilities are insufficient for the modern and future battlefield. To safeguard against radio-controlled threats and disrupt enemy communications, our current EW systems blindly jam broad swaths of the electromagnetic spectrum (EMS). This approach interferes with Blue Force data and voice communications, requires large power sources and generates distinct ...