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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Genetic Assay for Inhibitors of RNA-Protein Interactions

    SBC: ADVANCED GENETIC SYSTEMS, INC.            Topic: N/A

    RNA-protein interactions play critical roles in cellular regulatory processes and in the life cycles of many pathogenic viruses including HIV, hepatitis C, SARS, and West Nile virus, and thus represent attractive targets for therapeutics. We have developed novel cell-based assays to identify drugs that target the RNA-protein interactions. The assays incorporate a system of genetic reporters to acc ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  2. High Resolution Digital Imaging X-ray Detectors

    SBC: Aguila Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The aim is to develop a high resolution, high contrast detector for digital x-ray imaging systems. The target detector would have a Detective Quantum Efficiency much greater than 80%, a limiting resolution of at least 10 lp/mm, ultra-low noise, linear response and a dynamic range of more than 14 bits. The proposal is to build such a detector by using CdZnTe c ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  3. Hydronic, High-Speed, Focal Thermal Stimulator

    SBC: ALA SCIENTIFIC INSTRUMENTS INC            Topic: N/A

    DESCRIPTION (provided by applicant): Cloning of hot and cold thermal receptors has advanced the understanding of the molecular basis of thermal sensation. Two (2) important remaining questions to be addressed are the identification of additional thermal receptor genes and the elucidation of the mechanism(s) that enable the receptor proteins to alter gating properties in response to changes in temp ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  4. Gene Expression and Diagnosis of Diabetes

    SBC: ARTHROCHIP, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Autoimmune diseases are difficult to diagnose, as the symptoms can be nonspecific. A single test that could readily distinguish between an autoimmune and non-autoimmune disorder would allow physicians to focus efforts on the specific disease that affects the patient. This is critical for diabetes mellitus (DM), which has two subsets, Type I and Type II. The sub ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  5. Automated Test of Word Recognition- Phase II

    SBC: AUDIOLOGY, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Over 5 million word recognition tests are administered annually by audiologists in the United States with an associated cost of more than $100 million. These tests are currently performed manually by highly trained audiologists. This application describes the Phase II development of automated clinical speech recognition tests using clinical test recordings and ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  6. Development of Vasoactive Therapeutic

    SBC: Azerx, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 30,000 patients per year in the US suffer from subarachnoid hemorrhage (SAH). Although SAH represents only 5-10% of strokes, its impact is proportionally much higher because SAH patients are typically younger (mean age is 50 years) than other stroke patients. Nearly half of SAH patients die from either the initial hemorrhage or secondary compli ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  7. Data acquisition system for noninvasive cancer detection

    SBC: Biophotonics Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of the proposal is to develop an automated data acquisition system for non-invasive quantitative cancer detection, screening, and monitoring, based on highly sensitive low volume real time PCR technique and capillary electrophoresis, apply this system for quantitative analysis of the telomerase activity and gene expression in single cancer ce ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  8. Modified Tetracycline Effect on Sepsis-Induced Mortality

    SBC: Collagenex Pharmaceuticals, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): It was our Specific Aim in Phase I to: 1) develop a clinically relevant indirect sepsis-induced acute respiratory distress syndrome (ARDS) model and 2) utilize this model to determine the efficacy of prophylactic COL-3 in preventing the onset of ARDS. Both goals of our Phase I study were achieved and the results are as follows: 1) we successfully developed an ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  9. Mandibular Bone transport Reconstruction Plate

    SBC: Custom Scientific            Topic: N/A

    DESCRIPTION (provided by applicant): Surgical excision of hard and soft tissues of the head and neck or high impact trauma can lead to lead to major tissue deficits. Reconstruction of the lower jaw typically involves bone, gingiva, and teeth. Current mandibular distraction devices are used in combination with reconstruction plates, but while the reconstruction plates take the contour of the jaw, t ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  10. Life Belt CPR: Sternal Compression and Thoracic Constraint

    SBC: Deca-Medics            Topic: N/A

    DESCRIPTION (provided by applicant): In the United States, more than 250,000 persons annually experience out-of-hospital sudden cardiac death (SCD). However, few, approximately 4%, are revived with standard CPR and advanced life support interventions and survive to be discharged from the hospital. Successful restoration of cardiac function after SCD is dependent on early electrical defibrillati ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
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