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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Measurement of Beta Cell Death in Diabetes

    SBC: L2 DIAGNOSTICS, LLC            Topic: 200

    DESCRIPTION provided by applicant All forms of diabetes are characterized by the death of insulin producing cells In Type diabetes T D this leads to the reliance on exogenous insulin for survival Death of cells is silent it cannot be detected in vivo until it has progressed to such an extent that metabolic function is impaired The loss of cells has only been assessed by functiona ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Validation of a Negative Regulator as a Novel Therapy for Autoimmune Disease

    SBC: Immunext, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Systemic lupus erythematosus SLE is a devastating autoimmune disease that most commonly affects women in their child bearing years SLE attacks multiple organ systems but renal and neurologic involvement are the usual harbingers of poor outcome Despite effective albeit toxic immunosuppressive therapy only of patients with these serious manifestations ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. A Multivalent Lyme Disease Vaccine Targeting Tick-Host-Pathogen Interactions

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    DESCRIPTION provided by applicant This proposal seeks to develop a novel vaccine against Lyme disease by targeting Ixodes scapularis proteins critical for Borrelia burgdorferi transmission from the tick to mammalian host Earlier work has identified four tick proteins Salp TRE tHRF and TSLPI that facilitate different steps of spirochete transmission and immunity against these protein ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. RNA Detection as an Improved Diagnostic Assay for Human Leptospirosis

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    DESCRIPTION provided by applicant Leptospirosis a zoonotic disease is an important public health problem worldwide It is caused by spirochete bacteria belonging to nine species and more than serovars of the genus Leptospira In the US there is increasing awareness of the importance of leptospirosis as the cause of disease among inner city populations military personnel and individuals ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Practical Traveling Wave Parametric Amplifier for Quantum Computing and Mixed Signal Applications

    SBC: SOLID STATE SCIENTIFIC CORPORATION            Topic: A14AT010

    A collaboration between research engineers at Solid State Scientific Corporation and the University of MassachusettsBoston proposes the exploration of a new class of superconducting traveling wave parametric amplifier (TWPA) that exploits the large nonlinear inductance of a unique quantum device known as a superinductor. The nonlinear properties of the superinductor provide high gain of weak sign ...

    STTR Phase I 2014 Department of DefenseArmy
  6. Near Real-Time Quantification of Stochastic Model Parameters

    SBC: APPLIED MATHEMATICS INC            Topic: A13AT009

    Mathematical models of physical and biological systems contain parameters that need to be estimated from measured data. Models with parameters distributed probabilistically require the estimates of a probability measure over the set of admissible parameters. We propose to use frequentist-based approaches for non-parametrically estimating probability measures that describe the distribution of par ...

    STTR Phase II 2014 Department of DefenseArmy
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