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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Small molecule inhibitors targeting oncogenic drivers of hepatocellular carcinoma

    SBC: L2 DIAGNOSTICS LLC            Topic: 102

    DESCRIPTION provided by applicant Hepatocellular carcinoma HCC is the most prevalent cancer in human population and will lead to over deaths in the United States this year alone However the molecular mechanisms driving hepatocellular carcinoma HCC growth and metastasis remain elusive and there is a huge unmet medical need to find new therapeutic targets We performed an unbiased ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Simultaneous kinetic analyses of neuronal connectivities

    SBC: CIENCIA INC            Topic: 101

    DESCRIPTION provided by applicant Aberrant neuronal connectivity is associated with a number of neuropathological and neuropsychiatric diseases disorders Inefficient developmental connectivity misdirected connectivity or disrupted and degenerated connectivity can account for losses of normal neuronal communication and subsequent losses of mental or physical health Altered expression of axon ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Topical application of heterologous protein-expressing Staphylococcus epidermidis for potential therapeutic treatment of skin diseases

    SBC: Azitra Inc.            Topic: NIAID

    PROJECT SUMMARY Current treatment options for a number of skin diseases generally aim for symptomatic relief and fail to address underlying pathophysiological changes leading to skin disease In the case of genetic mutations that cause loss of function mutations supplementation of the missing protein is a viable approach to treatment However delivery of functional protein to the target keratino ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Therapeutic inhibition of P. aeruginosa nitrogen respiration in chronic infection

    SBC: L2 DIAGNOSTICS LLC            Topic: NIAID

    DESCRIPTION provided by applicant The goal of this STTR is to identify novel small molecule compounds targeting the nitrogen respiration pathway of Pseudomonas aeruginosa This pathway is crucial to the pathogenesis of P aeruginosa in vivo but has not yet been exploited for antimicrobial drug discovery There is a clear need for new treatments to combat P aeruginosa infections Antibiotic re ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Development of small near infrared laser system capable of improving immune responses to vaccines laser based adjuvant

    SBC: Veralase LLC            Topic: NIAID

    DESCRIPTION provided by applicant The lack of vaccine adjuvants that are both safe and effective is an important public health problem and is a key research priority for the NIH NIAID No adjuvants have yet been approved for use with intradermal vaccines The goal of this phase II STTR project is to move a new adjuvant for intradermal vaccination small near infrared lasers that emit brief non ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. A Method to Increase Buprenorphine Treatment Capacity and Effectiveness

    SBC: CBT4CBT LLC            Topic: R42

    The goal of this fast track STTR proposal is to expand buprenorphine maintenance therapy for opioid dependent patients Over million people in the US are addicted to opiates Providing effective agonist therapy methadone or buprenorphine coupled with behavioral counseling greatly improves outcomes reduces morbidity and reduces societal costs Methadone maintenance treatment has been limit ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Fast and Flexible Differential Equation Model Fitting with Application to Pharmacometrics

    SBC: Metrum Research Group LLC            Topic: N16AT016

    Differential equations are widely used to analyze and simulate the dynamics of complex systems in the physical, biological and social sciences. Inferences with such models are challenging due to both statistical and computational complexity. Stan is a widely used, open-source, probabilistic programming language and Bayesian inference engine. We propose to extend Stan by incorporating solvers for o ...

    STTR Phase I 2016 Department of DefenseNavy
  8. High Performance Energetic Propellant Ingredient Process Research and Development

    SBC: NALAS ENGINEERING SERVICES INC            Topic: N16AT021

    Current state of the art oxidizers have been in service for decades, leaving the performance of our munitions and propulsion systems unchanged while our tactical objectives have increased in their requirements. Keeping with ongoing changes in the worlds military, maintaining a tactical advantage while meeting or exceeding mission capability requirements is of utmost importance for our nation. As s ...

    STTR Phase I 2016 Department of DefenseNavy
  9. High Performance Energetic Propellant Ingredient Process Research and Development

    SBC: NALAS ENGINEERING SERVICES INC            Topic: N16AT021

    Current state of the art oxidizers have been in service for decades, leaving the performance of our munitions and propulsion systems unchanged while our tactical objectives have increased in their requirements. Keeping with ongoing changes in the worlds military, maintaining a tactical advantage while meeting or exceeding mission capability requirements is of utmost importance for our nation. As s ...

    STTR Phase I 2016 Department of DefenseNavy
  10. Seabed Imaging System

    SBC: CREARE LLC            Topic: N14AT022

    Acoustic imaging is the preferred modality for mine detection. However, acoustic images are noisy and difficult to interpret due to acoustic clutter, the interaction of sound with the seafloor, and potential penetration of sound into the sediment with subsequent reflection. Creare is developing a Seabed Imaging System (SIS) capable of providing detailed information on both the topography and compo ...

    STTR Phase II 2016 Department of DefenseNavy
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