You are here
The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.
Development of a small molecule activator of integrin cell adhesion to enhance therapeutic responses to checkpoint blockade in cancerSBC: 7 Hills Pharma LLC Topic: 102
Recent FDA approvals of ipilimumabnivolumaband pembrolizumabwhich target checkpoint receptors cytotoxic T lymphocyte associated antigenCTLAand programmed deathPDhave ushered in a new era of cancer immunotherapy in metastatic melanomaDespite unprecedented overall survival benefits with combination therapythe incidence of complete responses are onlyimmune related adverse eventsirAEsare increasedand ...STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: MODULATION THERAPEUTICS, INC. Topic: 102
Project Summary Metabolic reprogramming plays a critical role in carcinogenesisin part due its ability to promote immune suppressive properties within tumorsHoweverit is unclear whether inhibition of fatty acid metabolism in tumors affects their immunogenicityHerewe show for the first time that inhibition of stearoyl CoA desaturaseSCDthe rate limiting enzyme involved in fatty acid synthesis conver ...STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Innovative BioChips LLC Topic: NIA
PROJECT SUMMARY Developing an Automated Yeast Dissection System for Aging ResearchAging is the single greatest risk factor for diseases that are principal causes of mortalityThe objectives of aging research are to discover key genes and pathways related to aging that may eventually contribute to retardation of aging and a delay in the onset of age associated diseasesThe budding yeast Saccharomyces ...STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health