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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A high resolution and high DQE detector optimized for mammography using single shot bi directional tri contrast imaging

    SBC: Sigray, Inc.            Topic: NIBIB

    DESCRIPTION provided by applicant X ray tricontrast imaging provides three different modes of contrast absorption contrast the mechanism behind how conventional medical X ray imaging equipment images phase contrast which provides up to X more contrast than absorption based contrast for soft tissue and scatter contrast which provides information of features at dimensions smaller than ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. A high throughput high resolution and high sensitivity scanning X ray fluorescence microprobe for elemental mapping in cell cultures and tissues for medical research and diagnosis

    SBC: Sigray, Inc.            Topic: 400

    DESCRIPTION provided by applicant Trace elements are well known to have critical roles in a wide variety of diseases including cancer and neurodegenerative diseases such as Alzheimerandapos s and Wilsonandapos s diseases Due to their biological importance there have been numerous studies performed with spectroscopy techniques such as laser ablation inductively coupled mass spectrometry LA I ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. A method for preparing unbiased miRNA sequencing libraries miR ACS

    SBC: Somagenics, Inc.            Topic: 172

    ABSTRACT This proposal addresses the problem of sequence bias in next generation sequencing NGS of small RNAs such as microRNAs miRNAs as well as fragments of larger RNAs Because dysregulation of miRNA expression has been implicated in cancer and other diseases accurate expression profiling of all miRNA sequences is important for understanding miRNA biology and for development of new biomark ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. A New Technique for Diabetic Foot Ulcers

    SBC: Noveratech LLC            Topic: 200

    ABSTRACT Diabetes is the leading cause of nontraumatic lower extremity amputations in the United States Diabetic foot ulcers DFUs are responsible for more hospitalizations than any other diabetic complications Currently even the best available treatments achieve only a healing rate for these wounds and this healing is often only temporary with a chance of recurring Our company has ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. A NOVEL APPROACH FOR PAIN TREATMENT WITHOUT OPIOID LIABILITIES

    SBC: ASTRAEA THERAPEUTICS, LLC            Topic: R44

    DESCRIPTION provided by applicant Every year about million adult Americans experience some form of pain a condition that costs the nation between $ billion and $ billion annually in lost productivity and treatment The recently released `National Pain Strategyandapos developed by the NINDSandapos s IPRCC recognizes acute and chronic pain as a serious and costly public health issu ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. A Web Enabled Database for Rapid Metagenomic Biocatalyst Discovery and Validation

    SBC: Radiant Genomics, Inc.            Topic: 300

    DESCRIPTION provided by applicant Radiant Genomics proposes to develop an integrated enzyme discovery service the Enzyme Variant Engine EVE built upon the largest cloned metagenomic sequence collection reported to date The goal is to combine a publicly accessible search engine richly annotated sequence database arrayed sample library and LIMS automation platform to deliver novel enzyme ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Advanced Image Analysis Tools for Diabetic Retinopathy Telemedicine Application

    SBC: EYENUK, INC.            Topic: N

    DESCRIPTION provided by applicant In this Phase IIB application we propose to commercialize and bring to market EyeArt a fully automated high throughput retinal image analysis based diabetic retinopathy DR screening tool which has been developed and already validated in bench tests on very large real world data by conducting formal clinical trials and integrating it into several clinica ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Advanced Image Analysis Tools for Diabetic Retinopathy Telemedicine Application

    SBC: EYENUK, INC.            Topic: NEI

    Abstract In this Commercialization Readiness Pilot CRP Program application we propose to commercialize and bring to market EyeArt a fully automated high throughput retinal image analysis based diabetic retinopathy DR screening tool which has been developed and already validated in bench tests on very large real world data by developing and executing a market access plan conducting a pi ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Advanced morphological analysis of cerebral blood flow for acute concussion diagnosis and return to play determination

    SBC: Neural Analytics, Inc.            Topic: 101

    Project Summary Abstract Between and million people each year suffer a mild TBI in the US alone Reliable diagnosis and prompt treatments are vital to managing the often serious short and long term sequelae resulting from mild TBI However a reliable objective and accurate method for mild TBI diagnosis outside of a hospital setting and in particular for determining RTP readiness has e ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. A mechanism based computational tool to optimize pulmonary drug delivery

    SBC: CFD Research Corporation            Topic: 300

    DESCRIPTION provided by applicant Pulmonary drug delivery has emerged as a noninvasive alternative route for the treatment of lung diseases asthma COPD CF and lung cancer In order to obtain the desired level of effectiveness and safety of the inhaled drugs an appropriate deposition on the targeted region and subsequent absorption in the targeted region is vital Multiscale multidisciplin ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
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