Award Data

Oceanit proposes to research and develop chemical or non-chemical methods and processes to impart surface morphology modifications to aluminum-magnesium (Al-Mg) alloys to mitigate and increase the exfoliation corrosion resistance.

Psychostimulant abuse is a significant public health problemwithmillion Americans reporting cocaine use andmillion reporting methamphetamine useCurrentlythere are no FDA approved pharmacotherapies to treat stimulant dependencePrevious cocaine medications development efforts have focused on small molecule drugs as they can readily enter the brainThe lack of brain penetrance by large molecules was s ...

Principal Investigators for Small BusinessDiscoveryBioMedIncDBMand Monell Chemical Senses Center Project Summary Abstract Bitter taste in foods and medicines presents a barrier to overcoming global public health challengesfood insecuritypoor nutritional healthand poor compliance with medication useparticularly among children and the elderlySugar and saltthe mainstays to address these challengesfur ...

Traumatic brain injuryTBIis a substantial health care issue affecting both civilian and military populationsAlthough extremes of head injury are recognizablemild to moderate TBImmTBIis more difficult to diagnose leading to a need for the identification of circulating biomarkers of brain injury that may facilitate early identificationUsing a rat model of TBI we identified a novel marker of neuronal ...

SummaryThe goal of this proposal is to develop and validate a cost effectiveeasy to use and fully integrated navigation system for needle placement during CT image guided cancer diagnosis and treatmentBackgroundAccurate diagnostic and therapeutic interventions depend on accurate needle insertionwhich is subject to the physicianandapos s visuospatial ability and experienceand could be difficult in ...

Friction stir welding (FSW) is an attractive joining method where high strength low porosity welds can be attained. However, the high temperatures and forces required for welding high strength materials like steel require the use of exotic tools. Cubic boron nitride (cBN)-based tools offer attractive tool wear characteristics in steels, but are very costly. Conversely, refractory metal alloys are ...

Abstract Chronic liver injury due to alcohol, metabolic dysfunction, viral hepatitis, or autoimmune disease results in liver inflammation and fibrosis. Liver fibrosis will progress to cirrhosis which is estimated to affect 1–2% of the world’s population. The major clinical consequences of cirrhosis are liver failure and hepatocellular carcinoma (HCC), both of which increase the risk of death. ...

Abstract Pancreatic cancers are devastating diseases with five year survival rate less thanCurrentlythere is no effective treatment for advanced diseaseOne major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal responseEvidence suggests that cancer associated pancreatic stellate cellsCAPaSCproduce the stromal collagenThe ECM laid down by CAPaSC is considered to be o ...

The U.S. Navy currently utilizes a number of towed systems from surface ship and submarines for sensing and communication applications. In a number of these cases, a tow cable extends either down from a surface ship or up from a submarine through the upper part of the water column where seawater temperature can be both highly variable vs. depth and dynamic in time and geographic location. Having a ...

ABSTRACT Vaccine adjuvants help stimulate the body to generate an immune response when co injected with an antigenthe compound for which immunity is desiredAlthough the human body is capable of producing antibodies to most injected antigensadjuvants can help boost the body s ability to mount a successful and acquired immune response to the presented targetAdjuvants have been shown to enhance immun ...