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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Automated Contingency Management System for Reduction of Alcohol Use

    SBC: Managed Health Connections LLC            Topic: 450

    Project Summary Abstract Alcohol abuse remains a significant cause of preventable morbidity and mortality in the USYet onlyof those with AUD receive treatmentOur groupand others have demonstrated that contingency managementCMis an effective approach for reducing alcohol use in problematic drinkersThis project seeks to demonstrate the capability of an end to end CM platform designed to reduce alcoh ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Bitter Human Taste Bud Epithelial Cell Platforms for Bitter Taste Antagonist Discovery

    SBC: DISCOVERYBIOMED, INC.            Topic: NIDCD

    Principal Investigators for Small BusinessDiscoveryBioMedIncDBMand Monell Chemical Senses Center Project Summary Abstract Bitter taste in foods and medicines presents a barrier to overcoming global public health challengesfood insecuritypoor nutritional healthand poor compliance with medication useparticularly among children and the elderlySugar and saltthe mainstays to address these challengesfur ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Commercialization of a Rapid Blood Test for Traumatic Brain Injury

    SBC: Fawkes Biotechnology, LLC            Topic: 100

    Traumatic brain injuryTBIis a substantial health care issue affecting both civilian and military populationsAlthough extremes of head injury are recognizablemild to moderate TBImmTBIis more difficult to diagnose leading to a need for the identification of circulating biomarkers of brain injury that may facilitate early identificationUsing a rat model of TBI we identified a novel marker of neuronal ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a Spirulina-based oral malaria vaccine

    SBC: Lumen Bioscience, Inc.            Topic: NIAID

    ABSTRACT Vaccination represents the single most effective and cost effective medical intervention devised to datesaving lives and reducing morbidity and disability for billions of humansDespite the early success of the oral polio vaccinemost vaccines are delivered parenterallyand as such are associated with painnon compliancebiohazardous medical waste and strict requirements for expensive producti ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Evaluating Synthetic Biology Produced Triterpene Oils in Adjuvant Formulations

    SBC: Enepret Incorporated            Topic: NIAID

    ABSTRACT Vaccine adjuvants help stimulate the body to generate an immune response when co injected with an antigenthe compound for which immunity is desiredAlthough the human body is capable of producing antibodies to most injected antigensadjuvants can help boost the body s ability to mount a successful and acquired immune response to the presented targetAdjuvants have been shown to enhance immun ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Highly Multiplexed Analysis of Solid Tumors and Liquid Tissues by Cyclic Immunofluorescence

    SBC: RareCyte, Inc.            Topic: 102

    PROJECT SUMMARY The long term goal of this proposal is to developvalidate and market robustcost effective technologies for highly multiplexed imaging of cells in liquid and solid biopsies at sub cellular resolution as a means to diagnose diseaseidentify patients likely to benefit from specific anti cancer drugsand investigate mechanisms of action of cytoxictargeted and immuno oncology drugsThis wi ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Highly Sensitive Chimerism Testing to Detect Early Leukemia Relapse Post-Allo-Transplantation

    SBC: Chimerocyte, Inc.            Topic: 102

    ABST RACT Patients with acute blood malignancies who undergo allogeneic hematopoietic stem cell transplantationHSCTare monitored for minimal residual diseaseMRDas predictive of relapseIncreasing mixed chimerismreemerging recipient cellscorrelates with reappearance of underlying disease by association with MRDGenetic and immunophenotypic heterogeneity of these malignancies often prevents establishi ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point ofCare Applications

    SBC: GENECAPTURE            Topic: CBD15C001

    GeneCapture, Inc. is proposing to develop a rapid in vitro diagnostic prototype using our patented molecular-based CAPTURE (ConfirmActive Pathogens Through Unamplified RNA Expression) assay. Based on the results and experience gained in our Phase I STTR contractHDTRA1-16C-0061: Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications, we p ...

    STTR Phase II 2018 Department of DefenseOffice for Chemical and Biological Defense
  9. Noninvasive Seizure Screening in Preclinical Models of Epilepsy

    SBC: SIGNAL SOLUTIONS, LLC            Topic: 100

    Noninvasive Seizure Screening in Preclinical Models of Epilepsy There is an urgent need for research into treatment options for epilepsy and other seizure disordersAnimal models are increasingly used to understand disease mechanisms and to screen promising therapeutic approachesAnimal epilepsy model use typically requires expensive and labor intensive experimentationwith invasive EEG measurements ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Circulating RNA-based Markers as Diagnostic Biomarkers of Infectious Diseases

    SBC: CFD Research Corporation            Topic: CBD18A001

    In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

    STTR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
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