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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Drug target identification using CRISPRi/a screening

    SBC: BIOIO, LLC            Topic: 400

    ABSTRACT As phenotypic screening makes a comeback in drug discovery, its major issue is drug target identification. There aren’t good generalizable approaches to do target identification for compounds of interest. Identifying how a new drug works at the molecular level is critical for improving it, which is often needed to give it the best chance of ultimately being both safe and effective in pa ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Multi-Modal Venus Clot Removal Device

    SBC: Caeli Vascular LLC            Topic: NHLBI

    ABSTRACTThis Phase I STTR application from Caeli Vascular, LLC entails a 12-month period focused on the development of a novel endovascular venous thrombectomy device. The PI is a vascular surgeon with biomedical research and entrepreneurship experience, and is supported by a team of highly qualified investigators, including a vascular biologist, neurosurgeon, veterinarian, biomedical engineer, me ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Novel insulin-sensitizing NASH/diabetes drugs.

    SBC: BIOIO, LLC            Topic: 300

    Obesity is associated with an increased risk of a number of chronic and progressive diseases and obesity- related metabolic diseases constitute a significant public health burden. The increased likelihood of developing insulin resistance and diabetes is probably the most commonly recognized risk of being obese. In addition, obesity is also associated with accumulation of lipid in the liver parench ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  4. A Deep Learning Model to Improve Pathologist Interpretation of Donor Kidney Biopsies

    SBC: PlatformSTL (DBA for NewVentureIQ LLC)            Topic: 400

    ABSTRACT More people die every year from kidney disease than breast or prostate cancer. Kidney transplantation is life-saving, yet the donor organ shortage and high organ discard rate contributes to 13 deaths daily among patients awaiting transplant. The decision to use or discard a donor kidney relies heavily on microscopic quantitation of chronic damage by pathologists. The current standard of c ...

    STTR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Fatigue Prediction for Additive Manufactured (AM) Metallic Components

    SBC: Product Innovation And Engineering, LLC            Topic: N19BT026

    In this Phase I work, we will expose the effects of an additively-manufactured (AM) part’s inherent defects (including both volumetric and surface defects) and residual stress on its subsequent fatigue strength based on carefully-executed manufacturing, microstructure characterization, numerical simulations, and mechanical experiments. Results from this study will leverage consolidated design an ...

    STTR Phase I 2020 Department of DefenseNavy
  6. Additive Manufacturing of Inorganic Transparent Materials for Advanced Optics

    SBC: Product Innovation And Engineering, LLC            Topic: N19BT028

    The goal of the Phase I project is to demonstrate the feasibility of an AM process capable of depositing the required optical properties, full densification, and smooth surface finish through modeling the glass AM processing, developing the path planning for printing freeform optics, and evaluating the quality of the printed freeform optics with the proposed FFL . The specific objectives of the pr ...

    STTR Phase I 2020 Department of DefenseNavy
  7. Innovative Processing Techniques for Additive Manufacture of 7000 Series Aluminum Alloy Components

    SBC: Product Innovation And Engineering, LLC            Topic: N18AT005

    By using a combination of a highly Gaussian laser beam source, wavelength beam combining and multiple laser beam energy (MBE) PINE and Missouri S&T have successfully demonstrated the ability to create and stabilize Meltpools on all aluminum alloys investigated in Phase I. The MBE system has successfully processed several aluminum alloys with the potential to meet the performance needs of replacing ...

    STTR Phase II 2020 Department of DefenseNavy
  8. Developing a Nutraceutical Product against Ototoxicity

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    PROJECT SUMMARYDespite recent advances in cancer therapiesplatinum based drugs are still widely used for the treatment of solid tumorsA primary example is cisplatinwhich is frequently used to treat lungbladdertesticularand cervical cancersHoweverlimitations of this therapy include the development of drug resistance in cancer cells as well as severe side effectssuch as nephrotoxicity and neurotoxic ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Rapid high-resolution typing of Human Leukocyte Antigen genes by nanopore sequencing for transplantation

    SBC: PlatformSTL (DBA for NewVentureIQ LLC)            Topic: NIAID

    ABSTRACT Human leukocyte antigenHLAtyping is an essential laboratory test to evaluate the donor recipient compatibility before life saving transplantationsInaloneHLA typing of donors and recipients guided overorgan and stem cell transplantations in the United StatesExisting high resolution HLA typing methods require a turnaround time of days to weeksThere has been an unmet clinical need for a rapi ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Biologically Targeted Vaccine for Chikungunya

    SBC: PRECISION VIROLOGICS INC            Topic: NIAID

    PROJECT SUMMARY ABSTRACT Chikungunya virusCHIKVis a mosquito transmitted alphavirus that causes explosive epidemics of a severe febrile illness characterized by debilitating polyarthralgia in humansCHIKV caused an estimatedmillion new cases in India alone inand has the potential to spread globally because of the distribution and abundance of its mosquito vectorsAedes aegypti and Aedes albopictusDu ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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