Award Data

Project Summary / Abstract Chemotherapy induced peripheral neuropathy (CIPN) is a major side effect of oxaliplatin, a key drug in 1st line regimens for treating colorectal cancer. Dose-limiting CIPN prevents rt25% of patients from receiving full, maximally effective dose of oxaliplatin. In addition, 10-40% of patients receiving oxaliplatin-based therapy for colorectal cancer with develop chronic C ...

PROJECT SUMMARYLoss of functional mobility associated with aging is the leading cause of dangerous falls and loss of living independence. Approximately 60% of community-residing individuals rt80 years-old have a gait disorder, and abnormal gait patterns are associated with a greater than two-fold increased risk of institutionalization and death in comparison to age-related adults without gait impa ...

Age-related hearing loss (ARHL) is the predominant neurodegenerative disease of aging. Recent animal studies have demonstrated that the earliest cochlear pathology due to noise and aging involves a loss of the inner hair cell ribbon synapse. The early consequences of this synaptic loss are not believed to affect hearing sensitivity, but rather, impair speech understanding in background noise. Whil ...

PROJECT SUMMARY Sarya LLC (Sarya) is a nuclear medicine technology company formed to commercialize radiopharmaceuticals. The goal of this Fast-Track STTR is to develop a new specific imaging agent for diagnosis, staging, and treatment of the hematological cancer, multiple myeloma (MM). MM is the 2nd most common blood cancer with an estimated 32,000 new cases and 13,000 deaths per year. Accurate de ...

Research in Flight, Utah State University, MIT, and Syracuse University are proposing the development of a unified hypersonic aircraft design tool that integrates the hypersonic flow analysis capabilities of the commercial FlightStream® flow solver with t

Quantum computer technology is critical and strategic to the Air Force. Quantum processor technology based on topological material (TM) qubits is inherently stable and fault-tolerant because it exploits local topological symmetries. TM are a new class of

As part of updating the Minuteman III Intercontinental Ballistic Missile (ICBM) to the Sentinel ICBM, Launch Facilities (LF) and Launch Control Centers (LCC) will need improved flame protection systems. These facilities shall be supported by large Lithium

The IS4S/Auburn approach will be centered about a Continuous Output Microwave Energy Transformer (COMET) leveraging new GaN on SiC components from leading multi-million dollar research facilities and manufacturers with the purpose of developing novel Solar Power Satellite RF-DC solutions. This approach will navigate the entire DC-RF process from DC input to antenna port while running at a minimum ...

Assured Positioning, Navigation, and Timing (PNT) and robust communications are critical in maintaining overmatch in today's rapidly evolving electronic attack landscape. While existing PNT systems have been relied upon for years, their vulnerabilities to

Airmen are continually exposed to high stress situations that require them to perform with high precision. Both chronic and acute stress exposure can impair an individual’s performance, even in far less stressful scenarios. The body responds to high stres