Award Data

Project Summary / Abstract Chemotherapy induced peripheral neuropathy (CIPN) is a major side effect of oxaliplatin, a key drug in 1st line regimens for treating colorectal cancer. Dose-limiting CIPN prevents rt25% of patients from receiving full, maximally effective dose of oxaliplatin. In addition, 10-40% of patients receiving oxaliplatin-based therapy for colorectal cancer with develop chronic C ...

PROJECT SUMMARYLoss of functional mobility associated with aging is the leading cause of dangerous falls and loss of living independence. Approximately 60% of community-residing individuals rt80 years-old have a gait disorder, and abnormal gait patterns are associated with a greater than two-fold increased risk of institutionalization and death in comparison to age-related adults without gait impa ...

Age-related hearing loss (ARHL) is the predominant neurodegenerative disease of aging. Recent animal studies have demonstrated that the earliest cochlear pathology due to noise and aging involves a loss of the inner hair cell ribbon synapse. The early consequences of this synaptic loss are not believed to affect hearing sensitivity, but rather, impair speech understanding in background noise. Whil ...

PROJECT SUMMARY Sarya LLC (Sarya) is a nuclear medicine technology company formed to commercialize radiopharmaceuticals. The goal of this Fast-Track STTR is to develop a new specific imaging agent for diagnosis, staging, and treatment of the hematological cancer, multiple myeloma (MM). MM is the 2nd most common blood cancer with an estimated 32,000 new cases and 13,000 deaths per year. Accurate de ...

Additive Manufacturing (AM) has enabled the fabrication of complex part geometries and provided design freedom. However, part quality has been an inhibitor to widespread industry adoption. For Laser Powder Bed Fusion (LPBF) process, a focused laser energy

Warfighters operating in forward-deployed and stateside airspace environments lack central situational awareness and decision support capabilities which detract from mission-critical functions including flight safety, air traffic management, integrated ai

Thrust AI, in partnership with MIT Lincoln Labs, proposes to research and develop a proof-of-concept system architecture leveraging machine learning and modern extra-visual spectra sensing to accomplish real-time air traffic control (ATC) detection, recognition, and observation of aircraft in the terminal environment. The STTR Phase I effort will determine the technical feasibility, to the maximum ...

Additive manufacturing (AM) has enabled the fabrication of complex designs and highly customized parts previously impossible with traditional manufacturing. The need for specialized tooling is replaced by a heated extruder-nozzle assembly that melts the i

This study explores the integration of modern positioning technologies to concept an automation system providing in-transit visibility (ITV) of aircraft component deliveries like fuel and mission capable parts (MICAPS). The scope of this Phase I feasibili

Need to add info