Award Data

PROJECT SUMMARY Pneumococcal pneumonia remains the leading cause of bacterial pneumonia in both children under years of age and adults over years of age The standard preventative therapy is the conjugate vaccine Prevnar which consists of an immunogenic carrier protein covalently attached to one of thirteen pneumococcal capsular polysaccharides Although Prevnar has significantly red ...

PROJECT SUMMARY There is need for an artificial oxygen O carrier to substitute for banked blood in settings where stored blood is unavailable pre hospital care transport austere environments undeveloped countries or undesirable transfusion risk exceeds benefit To address this need we developed ErythroMer EM a first in class nano cyte blood substitute EM is a deformable ...

PROJECT SUMMARY In spite of recent new drug developments platinum based drugs such as cisplatin are still widely used to treat solid organ malignancies Besides its limited efficacy serious side effects have been associated with the use of cisplatin such as bilateral and irreversible hearing loss In the cochlea cisplatin can trigger the production of reactive oxygen species and activate sev ...

PROJECT SUMMARY The most common occupational and environmental hazard in this country is noise Itandapos s not surprising then that noise induced hearing loss NIHL is the second most common form of sensorineural hearing deficit behind only age related hearing loss presbycusis Although therapeutics that target the free radical pathway have shown promise for reducing NIHL there are no effe ...

Despite the myriad major advances in cardiology the prognosis for patients with severe medically refractive heart failure HF is exceedingly poor Approximately deaths occur annually in patients with HF who have endured an impaired quality of life often accompanied by significant economic and personal losses due to recurrent hospitalizations At least of these deaths were directl ...

Integrated Solutions for Systems, Inc. (IS4S) and teammate Auburn University (AU) propose to develop a PNT initialization system for dismounted soldiers. The proposed system will enhance warfighters ability to operate immediately in a GPS denied environments once their mission begins and has wide commercialization potential outside of DoD. In Phase I, the feasibility and expected benefits of inte ...

The overall objective of this project (Phase I, II, and III) is to develop, fabricate, and test a novel biofidelic rat surrogate for the validation of primary blast loading conditions for mild traumatic brain injury (mTBI). The CFDRC/NJIT team will use extensive knowledge of blast loading characteristics and TBI studies coupled with past/ongoing efforts designing and testing a rat surrogate. In P ...

The proposed Small Business Technology Transfer (STTR) Phase I project will determine the technical feasibility and cost-effectiveness of utilizing emerging blended-reality technologies that enable interoperability with LVC simulations to create more effective and comprehensive Battlefield Airmen training environments. The proposed training technologies will be integrated across multiple platforms ...

Several birds and insects use sky features such as sun, moon or star positions, sky polarization and even forest canopy structures to navigate and maintain heading in day or night conditions. To better understand this ability in insects, a sky projector is needed to allow researchers to project realistic sky images to the insect so that insect response can be studied. Polaris proposes to partner ...

High Velocity Penetrator Weapons experience severe stress in terms of high frequency vibration and shock during launch, flight, and on impact. The extreme conditions have significant impact on the survivability of the weapon due to damage of the energetic material and fuze compartment. Molecular dynamics is often used to understand the effect of external shock on the material. However, molecular ...