Award Data

The Navy intends to start using a significant quantity of composite structures in surface ship construction in an effort to decrease costs as well as to reduce the visibility of the ships to radar. The large size of the target structures necessitates the use of low temperature, non-autoclave processing techniques such as Vacuum Assisted Resin Transfer Molding (VARTM). In the recent past, most m ...

This effort joins the MEMS-based deformable mirror technology available from AgilOptics, a New Mexico small business, with the aero-optics technology of the University of Notre Dame to develop an Aero-optics Simulator. This simulator will develop a library of aero-optics patterns to simulate atmospheric distortions for test and evaluation of military or commercial beam control systems.

Off-board vehicles deployed in littoral environments are subjected to severe operational loads, including wave slamming, high-speed collision with debris, and underwater explosions. They additionally serve as sensor platforms, and would benefit from reduced self- and radiated noise for towed array performance and mine defense. Consequently, we propose to exploit the flexibility of design offered ...

We propose to develop a computer based system for the online analysis of bio-behavioral signals associated with momentary loss of alertness. We will continue our development of bio-behavioral measures indicative of lapses in alertness. Our system will use only measures that can be obtained without attaching sensors to the operator. We will concentrate on monitoring the oculomotor system using came ...

U.S. Government personnel deployed in tropical and neotropical regions continue to be at risk for developing malaria. Drug resistant malaria parasites are becoming more common in these areas, increasing the risk of American personnel developing a serious, life-threatening disease. Cross resistance between drugs is becoming much more common. Due to the emergence of drug resistance, derivates of k ...

DESCRIPTION (provided by applicant): The purpose of the proposed research is to develop methods to create immune protected universal donor cloned transgenic pigs for xenotransplantation. According to the United Network of Organ Sharing (UNOS) more than 30,000 organ transplants are performed in the US alone, yet greater than 95,000 people are currently on the waiting list to receive donors organs f ...

The leading edge of the V-22 rotor blade is made of titanium and nickel abrasion strips bonded to the composite substrate. Although effective for rain erosion protection, nickel and titanium show poor sand erosion resistance. In addition, this metal and composite hybrid configuration limits working strain and fatigue life. This hybrid concept also hampers field serviceability and increases the ...

DESCRIPTION (provided by applicant): Turner syndrome (TS) is the most common genetic problem effecting women, with an incidence of 1 in 1,500 to 2,000 live female births and occurs when an entire, or portions of an X-chromosome is deleted. Phenotypic features include primary hypogonadism, renal abnormalities, and profound short stature. Yet, with growth hormone therapy, acceptable adult stature c ...

DESCRIPTION (provided by applicant): Breast cancer remains one of the most insidious and difficult to treat human malignancies, affecting thousands of individuals each year. Our proposed studies are aimed at developing a novel tumor immunotherapy by using cryptic peptides of Her-2 protein and modified Her-2 peptides, both of which break immune tolerance to ?self? tumor antigens expressed on breast ...

DESCRIPTION (provided by applicant): The overall goal of this project is to develop therapeutic antivirals to treat life-threatening flavivirus infections. Enfuvirtide, a clinically successful peptide HIV fusion inhibitor, is the prototype for a new class of antivirals that inhibit viral envelope protein structural rearrangements essential for viral entry into host cells. In preliminary experiment ...