Award Data

The objective of this project is to develop a multi-purpose combination type optical fiber sensor that enables simultaneous sensing of microstructural evolutions in the sensor materials and the environmental conditions such as pressure and temperature. It is very well known that materials subjected to fatigue and high temperature will go through microstructural changes such as plastic deformation, ...

Conventional computational docking typically takes a long time because it has a six-dimensional problem to solve - ligand orientation and ligand position - as well as conformational aspects. Reducing the dimensionality of the problem offers the opportunit

The purpose of the Power Generating Backpack is to allow soldiers to generate electricity while walking. This backpack represents an alternative to bulky battery systems soldiers often carry on the battlefield. The adoption of this backpack will result in a lighter load, thus improved comfort and mobility for combat units. The design APECOR is proposing will be transparent and of minimal impact t ...

DESCRIPTION (provided by applicant): Cardiovascular disease is the leading cause of morbidity and mortality in the United States, accounting for approximately 1 million deaths per year. The objective of the Phase I pre-clinical studies outlined in this fasttrack STTR proposal is to validate the proposed methods of isolation, characterization, and administration of preferred progenitor cell prepar ...

DESCRIPTION (provided by applicant): The emergence of technologies enabling isolation of adult stem cells has allowed evaluation of cell therapeutics for central nervous system disorders with a path for clinical development. Much promise has been shown using stem cells in acute disease models such as stroke or hypoxic injury to the brain, and as well to chronic degenerative diseases such as Park ...

We propose to develop a computer based system for the online analysis of bio-behavioral signals associated with momentary loss of alertness. We will continue our development of bio-behavioral measures indicative of lapses in alertness. Our system will use only measures that can be obtained without attaching sensors to the operator. We will concentrate on monitoring the oculomotor system using came ...

DESCRIPTION (provided by applicant): Case Western Reserve University researchers and BioInVision, Inc. will develop a cryo-imaging system for 3D imaging of mice. It will serve applications in stem cell regenerative medicine, metastatic cancer, and pathogen/immune system response, among others. By alternately sectioning and imaging, the system will enable one to acquire 3D high-resolution color and ...

The quench-protection strategy at 77 K identified in the Phase I STTR program involves depositing a thin film of a ceramic insulation having a large thermal conductivity at 77 K. Two ceramics were identified for this strategy, ZnO and Zn2GeO4, and in the Phase II STTR program the deposition properties of these ceramics will be explored (sputtering, ion-beam-assisted sputtering, pulsed laser depos ...

DESCRIPTION (provided by applicant): Evidence-based treatment for pediatric bipolar disorder (BPD) is sorely lacking. While pharmacology remains the first-line treatment, psychosocial interventions are considered essential for comprehensive care. Currently there are no published large-scale, randomized clinical trials of psychosocial intervention for pediatric BPD; however, one is nearing completi ...

DESCRIPTION (provided by applicant): The blood-brain barrier (BBB) is crucial for complex issues such as drug delivery, pathogenesis of chronic neurological diseases involving BBB dysfunction (e.g., brain tumors, ischemia, hypoxia, brain edema, multiple sclerosis, and meningitis) and issues related to bio-defense. Since the BBB selectively (by specific transport mechanisms) excludes most blood-bor ...