Award Data

DESCRIPTION provided by applicant Modern radiation therapy treatment modalities such as intensity modulated radiation therapy are associated with complex dose distributions and sharp dose gradients Experimental dose validation using multidimensional high spatial resolution dosimeters is mandatory The product to be developed is a novel high resolution dosimetry system that combines reusabil ...

DESCRIPTION provided by applicant The proposed research is the study of new paradigms in both the treatment of cancer and cancer drug development This platform technology will markedly expand the number of cancer specific surface receptors and antigens that can be targeted for drug delivery using peptide ligands The general principle of this new technology is that cancer cells respond to ioni ...

DESCRIPTION provided by applicant This proposed project will further develop a CFC off loading AFO designed to offload plantar pressures and optimize patient function through maximizing plantarflexor power production During Phase I we will determine the effects of varying design characteristics of CFC off loading AFOs We will refine and create new FEA models and algorithms that predict the ...

DESCRIPTION provided by applicant Noise is the most common occupational and environmental hazard thus it is not surprising that noise induced hearing loss NIHL is the second most common form of sensorineural hearing deficit second only to age related hearing loss Although therapeutics that target the free radical pathway have shown promise for reducing NIHL there are no medications approv ...

DESCRIPTION provided by applicant Male hypogonadism results from failure of the testes to produce sufficient sex hormones Aging is the greatest cause of primary hypogonadism otherwise known as testosterone deficiency syndrome TDS and in the United States affects million men while undiagnosed cases of TDS are upwards of million men TDS adversely affects male health and has been lin ...

Project Summary Abstract High throughput screening HTS is a powerful method for the discovery of new drug leads for target enzymes In HTS assays the activity of the target enzyme is often evaluated by quantifying a small molecule or cofactor that is produced or consumed by the enzyme While antibodies are a mainstay of small molecule detection as says they do have severe limitations which a ...

The technical objectives of this proposal are: 1) Fabricate and test ridge-guide, quantum-cascade-laser (QCL) devices employing a broad-gain-spectrum active-region design and suitable for incorporation in the designed high-index-contrast (HC) photonic-crystal (PC) THz, difference-frequency-generation (DFG) QCLs ; 2) Fabricate and test large-aperture HC-PC QCL devices suitable for THz generation vi ...

CompuTherm, LLC proposes to develop innovative new generation software based on the CALPHAD method. This new software, named Pandat-Pro, will be built upon CompuTherms current Pandat software. The significant advances of Pandat-Pro are: (1) Bayesian analysis will be introduced to perform error analysis for both the optimized model parameters and the simulated properties; (2) a database management ...

We propose to develop a computer based system for the online analysis of bio-behavioral signals associated with momentary loss of alertness. We will continue our development of bio-behavioral measures indicative of lapses in alertness. Our system will use only measures that can be obtained without attaching sensors to the operator. We will concentrate on monitoring the oculomotor system using came ...

Friction Stir Processing (FSP) is an emerging technology that can be used to pre or post-process a range of materials, including aluminum, to locally modify material properties. It is known that FSP can be used to enhance material properties for improved superplastic forming (SPF) behavior of aluminum. This can potentially allow for dramatic cost reductions of SPF and aluminum fabrications, all ...