Award Data

We propose to develop a computer based system for the online analysis of bio-behavioral signals associated with momentary loss of alertness. We will continue our development of bio-behavioral measures indicative of lapses in alertness. Our system will use only measures that can be obtained without attaching sensors to the operator. We will concentrate on monitoring the oculomotor system using came ...

The need for an miniature sensor for chemical and biological materials of interest is discussed. Such sensors can be deployed on small sonochute-launched unmanned air vehicles to interrogate sea-borne vehicles. The design for a miniature UAV-borne sensor is proposed and discussed in detail. In Phase I, hardware will be built and flight tested. In the Phase I option, the design will be refined for ...

DESCRIPTION (provided by applicant): Highly multiplexed detection of biological molecules and their activities has been an essential element of modern molecular diagnosis, drug development and research in genomics and proteomics. Well established DNA array methodologies exist which permit highly multiplexed detection of transcripts. Similar methodologies for detecting or measuring activities of pr ...

The objective of this STTR Phase II proposal is to optimize the new generation nanocrystalline formulation that was downselected from the Phase I project, which would be superior to surface modified activated carbon in terms of adsorption capacity and sel

Surfaces Research proposes a Phase II STTR program to conduct further research with ionic liquid lubricants based upon our successful Phase I research. We have assembled a team for fundamental surface science and chemistry, tribology, microtribology, and molecular modeling to conduct this research. Additional team members will provide aerospace mechanism information and permit collaboration with A ...

DESCRIPTION (provided by investigator): Several viruses in the family Bunyaviridae are significant human pathogens and potential agents of bioterrorism. Vaccines against some of these viruses do exist, but with the exception of ribavarin, there are no broad-spectrum antiviral compounds capable of inhibiting replication of more than one member of the family. Using LaCrosse virus (LAC) as a prototyp ...

DESCRIPTION (provided by applicant): Databases of biological sequences have proven valuable for understanding the organization of human and other genomes, for unraveling the etiology of genetic disorders, and for studying medically important pathogens. Unfortunately, these databases are growing at an exponential rate, posing a severe problem for bio-sequence annotation. Specialized hardware implem ...

We have selected three technologies for the unobtrusive monitoring of bio-behavioral events. Camera-based measures of gaze, including eye and head movements, pupil diameter, vergence, and blink parameters; Laser Doppler Vibrometry (LDV) based measures of cardiovascular and muscle activity; and behavioral measures including movements of body parts as well as keyboard operations will be utilized. Ou ...

DESCRIPTION (provided by applicant): Paclitaxel has shown promise in the treatment of several types of cancers, including ovarian cancer. The long-term goals of this research are to design a formulation of paclitaxel that is effective in the treatment of cancer and exhibits no formulation related toxicity. The present set of studies utilizes the techniques of precipitation with compressed antisol ...

The proposed Phase II effort will result in the development of new devices for improving optical propagation of both directed energy and free space communication systems. The Phase I effort has demonstrated the feasibility of these devices. The Phase II effort will provide the optimization and maturation needed to bring them to the commercial markets through two paths. The first is a high frequ ...