Award Data

DESCRIPTION (provided by applicant): Nitric oxide (NO) is a critical regulator of cardiovascular physiology, coordinating the activities of the endothelium, the vessel wall and circulating cells to optimize the flow of blood and oxygen to tissues. Increasing the bioavailability of NO should provide therapeutic benefit in the treatment of many diseases ascribed to insufficient NO bioavailability. A ...

DESCRIPTION (provided by applicant): The long term goal of this research is to develop an efficient method to authenticate rodent cell lines. Misidentification as well as inter- and intra-species cross contamination of cell lines is widespread and has a substantial negative impact on biomedical research. The use of short tandem repeat (STR) analysis has been shown to be an effective means of authe ...

DESCRIPTION (provided by applicant): The overall goal of this proposal is to establish a novel freezing device that will prevent cell damage associated with extracellular ice formation during cryopreservation of rodent sperm. Rodent sperm have an unusual morphology compared to other mammalian species, with an asymmetric, falciform head and a relatively very long principle piece. They are also extr ...

DESCRIPTION (provided by applicant): The overall goal of this project is to establish new and novel methods and materials that will improve the low temperature storage of mammalian embryonic stem cells (ESCs). Here we propose to work only with mouse (i.e. non-human) ESCs. This work will result in intellectual property for the production of devices and disposables (e.g., media). ESCs are important ...

The noise from turbulent, hot, supersonic jets during take-off and landing, as well as high-Mach cruise at altitude, dominates noise emanating from other powerplant components (e.g., fan, combustor). This intense noise has significant safety implications for launch personnel as well an environmental impact in the form of noise pollution around military installations. The proposed work will build ...

DESCRIPTION (provided by applicant): Detection and quantification of proteins in various biological samples is one of the most important and most often utilized assays with applications in research, medical diagnosis, early disease detection and detection of biological threat agents. While many protein detection methodologies are available (ELISA being a gold standard of those), they each have som ...

Terbium and Europium doped glasses will be investigated for tunable lasing from 450 nm to 490 nm. They will be pumped by Q-switched frequency tripled 355 nm Nd laser pulses. The Tb materials will also be evaluated for 375 nm laser diode pumping.

We propose to develop a computer based system for the online analysis of bio-behavioral signals associated with momentary loss of alertness. We will continue our development of bio-behavioral measures indicative of lapses in alertness. Our system will use only measures that can be obtained without attaching sensors to the operator. We will concentrate on monitoring the oculomotor system using came ...

DESCRIPTION (provided by applicant): Highly multiplexed detection of biological molecules and their activities has been an essential element of modern molecular diagnosis, drug development and research in genomics and proteomics. Well established DNA array methodologies exist which permit highly multiplexed detection of transcripts. Similar methodologies for detecting or measuring activities of pr ...

"The proposed Phase 2 program focuses on the development of Powered Resonance Tube (PRT) actuators for application to Active Flow Control (AFC). For effective control across the full operating envelope of an air vehicle, high bandwidth and authority arerequired. In Phase 1, a new variable-frequency PRT actuator concept was developed and its feasibility was demonstrated. In Phase 2, the new actu ...