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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. New Assays for Expression Profiling of MicroRNAs

    SBC: Nawgen, LLC            Topic: 172

    DESCRIPTION provided by applicant MicroRNAs miRNAs are involved in many diverse biological processes and a single miRNA can modulate the expression of hundreds of gene targets Changes in miRNA expression could have profound biological impacts leading to a variety of human diseases To date most miRNA expression profiling studies have relied on microarrays or high throughput RNA sequencing ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Rational design of small interfering RNA for genome-wide target knockdown

    SBC: Nawgen, LLC            Topic: 172

    DESCRIPTION provided by applicant RNA interference RNAi is a small RNA guided gene silencing process within living cells The RNAi technique is widely used in both biological research and clinical applications because it has the ability to knockdown essentially any gene of interest However one major unresolved issue in RNAi studies is non specific gene silencing It is well known that in ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a humanized anti-CD47 antibody for treatment of tissue ischemia.

    SBC: VASCULOX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Nitric oxide (NO) is a critical regulator of cardiovascular physiology, coordinating the activities of the endothelium, the vessel wall and circulating cells to optimize the flow of blood and oxygen to tissues. Increasing the bioavailability of NO should provide therapeutic benefit in the treatment of many diseases ascribed to insufficient NO bioavailability. A ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  4. Rodent Cell Line Authentication

    SBC: IMPACT BIOLABS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The long term goal of this research is to develop an efficient method to authenticate rodent cell lines. Misidentification as well as inter- and intra-species cross contamination of cell lines is widespread and has a substantial negative impact on biomedical research. The use of short tandem repeat (STR) analysis has been shown to be an effective means of authe ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  5. Development of an Ice-Free Cryopreservation Device

    SBC: IMPACT BIOLABS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of this proposal is to establish a novel freezing device that will prevent cell damage associated with extracellular ice formation during cryopreservation of rodent sperm. Rodent sperm have an unusual morphology compared to other mammalian species, with an asymmetric, falciform head and a relatively very long principle piece. They are also extr ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  6. Fundamental Cryobiology of Mammalian Embryonic Stem Cells

    SBC: IMPACT BIOLABS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of this project is to establish new and novel methods and materials that will improve the low temperature storage of mammalian embryonic stem cells (ESCs). Here we propose to work only with mouse (i.e. non-human) ESCs. This work will result in intellectual property for the production of devices and disposables (e.g., media). ESCs are important ...

    STTR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  7. Large Eddy Simulations of Hot Supersonic Jets for Aeroacoustics

    SBC: INNOVATIVE TECH APPLICATIONS LLC            Topic: N09T008

    The noise from turbulent, hot, supersonic jets during take-off and landing, as well as high-Mach cruise at altitude, dominates noise emanating from other powerplant components (e.g., fan, combustor). This intense noise has significant safety implications for launch personnel as well an environmental impact in the form of noise pollution around military installations. The proposed work will build ...

    STTR Phase I 2009 Department of DefenseNavy
  8. Rapid homogeneous antibody-based detection of proteins

    SBC: MEDIOMICS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Detection and quantification of proteins in various biological samples is one of the most important and most often utilized assays with applications in research, medical diagnosis, early disease detection and detection of biological threat agents. While many protein detection methodologies are available (ELISA being a gold standard of those), they each have som ...

    STTR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  9. Wavelength Agile, High Energy, High Repetition Rate Blue Laser for Oceanographic LIDAR Purposes

    SBC: METASTABLE INSTRUMENTS, INC            Topic: N09T006

    Terbium and Europium doped glasses will be investigated for tunable lasing from 450 nm to 490 nm. They will be pumped by Q-switched frequency tripled 355 nm Nd laser pulses. The Tb materials will also be evaluated for 375 nm laser diode pumping.

    STTR Phase I 2009 Department of DefenseNavy
  10. Real-Time Detector of Human Fatigue

    SBC: Bio-Behavior Analysis Systems, LLC            Topic: AF04T007

    We propose to develop a computer based system for the online analysis of bio-behavioral signals associated with momentary loss of alertness. We will continue our development of bio-behavioral measures indicative of lapses in alertness. Our system will use only measures that can be obtained without attaching sensors to the operator. We will concentrate on monitoring the oculomotor system using came ...

    STTR Phase II 2006 Department of DefenseAir Force
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