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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Towards a New Generation of Glycoengineered Pneumococcal Bioconjugate Vaccines

    SBC: VaxNewMO            Topic: NIAID

    PROJECT SUMMARY Pneumococcal pneumonia remains the leading cause of bacterial pneumonia in both children under years of age and adults over years of age The standard preventative therapy is the conjugate vaccine Prevnar which consists of an immunogenic carrier protein covalently attached to one of thirteen pneumococcal capsular polysaccharides Although Prevnar has significantly red ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. ErythroMer Nanoscale Bio Synthetic Red Cell Substitute

    SBC: Kalocyte Inc            Topic: NHLBI

    PROJECT SUMMARY There is need for an artificial oxygen O carrier to substitute for banked blood in settings where stored blood is unavailable pre hospital care transport austere environments undeveloped countries or undesirable transfusion risk exceeds benefit To address this need we developed ErythroMer EM a first in class nano cyte blood substitute EM is a deformable ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Develop a new cisplatin based drug combination with reduced ototoxicity

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    PROJECT SUMMARY In spite of recent new drug developments platinum based drugs such as cisplatin are still widely used to treat solid organ malignancies Besides its limited efficacy serious side effects have been associated with the use of cisplatin such as bilateral and irreversible hearing loss In the cochlea cisplatin can trigger the production of reactive oxygen species and activate sev ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Developing a Nutraceutical Product against Noise Induce Hearing Loss

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    PROJECT SUMMARY The most common occupational and environmental hazard in this country is noise Itandapos s not surprising then that noise induced hearing loss NIHL is the second most common form of sensorineural hearing deficit behind only age related hearing loss presbycusis Although therapeutics that target the free radical pathway have shown promise for reducing NIHL there are no effe ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Fibrin Specific Nuclear Probe to Reduce LVAD Adverse Events

    SBC: CAPELLA IMAGING, LLC            Topic: NHLBI

    Despite the myriad major advances in cardiology the prognosis for patients with severe medically refractive heart failure HF is exceedingly poor Approximately deaths occur annually in patients with HF who have endured an impaired quality of life often accompanied by significant economic and personal losses due to recurrent hospitalizations At least of these deaths were directl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. New Assays for Expression Profiling of MicroRNAs

    SBC: Nawgen, LLC            Topic: 172

    DESCRIPTION provided by applicant MicroRNAs miRNAs are involved in many diverse biological processes and a single miRNA can modulate the expression of hundreds of gene targets Changes in miRNA expression could have profound biological impacts leading to a variety of human diseases To date most miRNA expression profiling studies have relied on microarrays or high throughput RNA sequencing ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. LADAR Light Reflection Analysis for Target Surface Characterization

    SBC: System Dynamics International Incorporated            Topic: A10AT006

    This Phase I STTR effort develops and tests spectropolarimetric surface characterization algorithms for LADAR based remote sensing. A systematic approach is used which first defines the operational scenarios for which the algorithms are to work. These scenarios are then used to define requirements for LADAR hardware and algorithms which serves to focus the algorithm development effort. A librar ...

    STTR Phase I 2010 Department of DefenseArmy
  8. Infrared Retroreflective, Visible Absorbing, and Electrostatically Adhesive Microsphere Taggants

    SBC: MO-SCI Corp.            Topic: A08T008

    MO-SCI Corporation and the Missouri University of Science & Technology (MST-formerly University of Missouri-Rolla) propose to develop low cost, IR retro-reflective (800 nm - 2800 nm), visible absorbing glass microspheres for ubiquitous spectroscopic tagging through our innovative material design, fabrication and characterization technologies. These glass microspheres of any size (e.g., 20 - 100 mi ...

    STTR Phase I 2008 Department of DefenseArmy
  9. Software System Reliability Analysis

    SBC: COGNITIVE CONCEPTS            Topic: OSD06SP4

    Establishing the reliability of embedded software-based systems is increasingly important as the DoD's dependency on software grows and the size and complexity of software systems increase. Currently, no theory is in general practice that adequately explains the behavior of software systems reliability in a consistent and repeatable way. Currently, we cannot point to a best practice (although Jo ...

    STTR Phase I 2007 Department of DefenseArmy
  10. Extreme Phase Change Materials for Soldier Microclimate Regulation

    SBC: Renewable Alternatives, LLC            Topic: A05T012

    Microclimate systems are being developed to minimize the effects of extreme temperature on performance capability and enable functioning under conditions that would otherwise cause incapacitation. It is important that these systems be highly reliable, lightweight and durable, with the intention to be worn under armor materials, heavy chemical/biological protective suits, and other protective cloth ...

    STTR Phase II 2007 Department of DefenseArmy

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