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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Innovative Processing Techniques for Additive Manufacture of 7000 Series Aluminum Alloy Components

    SBC: Product Innovation And Engineering, LLC            Topic: N18AT005

    The goal of this STTR Phase I research proposal is to develop a proof of concept for a novel additive manufacturing (AM) process that will be capable of processing 7000 series AM aluminum alloys while minimizing defects, with an eventual goal of Phase II/III project to commercialize the developed technology. To achieve this goal, the technical objectives, the proposed technology includes the follo ...

    STTR Phase I 2018 Department of DefenseNavy
  2. Towards a New Generation of Glycoengineered Pneumococcal Bioconjugate Vaccines

    SBC: VaxNewMO            Topic: NIAID

    PROJECT SUMMARY Pneumococcal pneumonia remains the leading cause of bacterial pneumonia in both children under years of age and adults over years of age The standard preventative therapy is the conjugate vaccine Prevnar which consists of an immunogenic carrier protein covalently attached to one of thirteen pneumococcal capsular polysaccharides Although Prevnar has significantly red ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. ErythroMer Nanoscale Bio Synthetic Red Cell Substitute

    SBC: Kalocyte Inc            Topic: NHLBI

    PROJECT SUMMARY There is need for an artificial oxygen O carrier to substitute for banked blood in settings where stored blood is unavailable pre hospital care transport austere environments undeveloped countries or undesirable transfusion risk exceeds benefit To address this need we developed ErythroMer EM a first in class nano cyte blood substitute EM is a deformable ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Develop a new cisplatin based drug combination with reduced ototoxicity

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    PROJECT SUMMARY In spite of recent new drug developments platinum based drugs such as cisplatin are still widely used to treat solid organ malignancies Besides its limited efficacy serious side effects have been associated with the use of cisplatin such as bilateral and irreversible hearing loss In the cochlea cisplatin can trigger the production of reactive oxygen species and activate sev ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Developing a Nutraceutical Product against Noise Induce Hearing Loss

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    PROJECT SUMMARY The most common occupational and environmental hazard in this country is noise Itandapos s not surprising then that noise induced hearing loss NIHL is the second most common form of sensorineural hearing deficit behind only age related hearing loss presbycusis Although therapeutics that target the free radical pathway have shown promise for reducing NIHL there are no effe ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Development of Fibrin Specific Nuclear Probe to Reduce LVAD Adverse Events

    SBC: CAPELLA IMAGING, LLC            Topic: NHLBI

    Despite the myriad major advances in cardiology the prognosis for patients with severe medically refractive heart failure HF is exceedingly poor Approximately deaths occur annually in patients with HF who have endured an impaired quality of life often accompanied by significant economic and personal losses due to recurrent hospitalizations At least of these deaths were directl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Optimized Build Plate Design Tool for Metal Laser Powder Bed Additive Manufacturing

    SBC: Product Innovation And Engineering, LLC            Topic: N17BT033

    The goal of this STTR Phase I research proposal is to develop a Support Structure Planning System (SSPS) that will be capable of optimizing the build plate layout for powder bed Additive Manufacturing (AM) processes . The objectives of this Phase I project are to demonstrate the feasibility of 1) automatic identification of the need for support structures; 2) non-contact support structure design f ...

    STTR Phase I 2017 Department of DefenseNavy
  8. New Assays for Expression Profiling of MicroRNAs

    SBC: Nawgen, LLC            Topic: 172

    DESCRIPTION provided by applicant MicroRNAs miRNAs are involved in many diverse biological processes and a single miRNA can modulate the expression of hundreds of gene targets Changes in miRNA expression could have profound biological impacts leading to a variety of human diseases To date most miRNA expression profiling studies have relied on microarrays or high throughput RNA sequencing ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. High Efficiency, JP-8 Fueled Refrigeration Cycles for Shelter Air Conditioning

    SBC: Thermavant Technologies, L.L.C.            Topic: OSD09T002

    The proposed JP-8 powered cooling technology was co-invented by ThermAvant Technologies, LLC and the University of Columbia-Missouri (MU). The technology is based on the ejector cooling cycle and has the following unique features: thermodynamically and fluid dynamically optimal working fluids for increased high heat transfer and reduced entropy generation; low-shock loss, momentum conserving eject ...

    STTR Phase I 2010 Department of DefenseNavy
  10. Compressible High Order Parallel Acoustics Solver

    SBC: INNOVATIVE TECH APPLICATIONS LLC            Topic: N09T008

    The noise from turbulent, hot, supersonic jets during take-off and landing, as well as high-Mach cruise at altitude, dominates noise emanating from other powerplant components (e.g., fan, combustor). This intense noise has significant safety implications for launch personnel as well an environmental impact in the form of noise pollution around military installations. The proposed Phase II work wil ...

    STTR Phase II 2010 Department of DefenseNavy

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