Award Data

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DESCRIPTION (Provided by Applicant): The objective of this Phase I proposal is to determine the scientific, technical, and commercial merit and feasibility of an integrated commercial treatment planning and dosimetry system (RTDS) for radionuclide therapy and radionuclide imaging, especially for radioimmunotherapy (AlT). In clinical and experimental RIT, ...

DESCRIPTION: The goal of this Phase I STTR program will be to develop an adjustable intra-ocular lens (IOL). The concept is novel and has the potential to reduce the rehabilitation time of patients receiving an artificial IOL. The proposed technique and design, in conjunction with traditional intra- ...

Maple Syrup Urine Disease (MSUD) is a recessive genetic disorder resulting from defects in the branched chain a-keto acid dehydrogenase complex (BCKAD). Infants with classic MSUD appear normal at birth, but can die within 2-3 weeks if untreated. Although generally rare (1:200,000 births), the incidence of MSUD in certain Mennonite communities is quite high (1:176 live births), and results from a s ...

DESCRIPTION (provided by applicant): The goal of the project is to develop new positive inotropes, represented by specifically modified AMP molecules. All of the currently available positive inotropic agents have significant adverse effects with digitalis being the only orally available positive inotrope. ATP causes a pronounced positive inotropic effect. Receptors for ATP, known as P2 purinergic ...

DESCRIPTION (provided by applicant): We have developed several tumor-specific and tissue-specific replication-competent adenoviruses (Ad) vectors for cancer gene therapy. One vector, named KD3, has a mutation in the E1A gene such that KD3 cannot replicate in, and destroy, "normal" cells. However, KD3 can replicate in cancer cells because they have a microenvironment conducive to KD3 replication. ...

DESCRIPTION (provided by applicant): We have developed several tumor-specific and tissue-specific replication-competent adenoviruses (Ad) vectors for cancer gene therapy. One vector, named KD3, has a mutation in the E1A gene such that KD3 cannot replicate in, and destroy, "normal" cells. However, KD3 can replicate in cancer cells because they have a microenvironment conducive to KD3 replication. ...

DESCRIPTION (provided by applicant): The efficacy of molecular chaperones as adjuvants for the induction of anti-tumor immunity has been demonstrated in many laboratories over the last two decades. Similarly, the exploration of the therapeutic use of poxviruses in cancer treatment has a long and diverse history. These findings have led us to hypothesize that poxviruses would be an efficient and e ...

DESCRIPTION (provided by investigator): Several viruses in the family Bunyaviridae are significant human pathogens and potential agents of bioterrorism. Vaccines against some of these viruses do exist, but with the exception of ribavarin, there are no broad-spectrum antiviral compounds capable of inhibiting replication of more than one member of the family. Using LaCrosse virus (LAC) as a prototyp ...

DESCRIPTION (provided by applicant): Databases of biological sequences have proven valuable for understanding the organization of human and other genomes, for unraveling the etiology of genetic disorders, and for studying medically important pathogens. Unfortunately, these databases are growing at an exponential rate, posing a severe problem for bio-sequence annotation. Specialized hardware implem ...