Award Data

Project Summary / Abstract Chemotherapy induced peripheral neuropathy (CIPN) is a major side effect of oxaliplatin, a key drug in 1st line regimens for treating colorectal cancer. Dose-limiting CIPN prevents rt25% of patients from receiving full, maximally effective dose of oxaliplatin. In addition, 10-40% of patients receiving oxaliplatin-based therapy for colorectal cancer with develop chronic C ...

PROJECT SUMMARYLoss of functional mobility associated with aging is the leading cause of dangerous falls and loss of living independence. Approximately 60% of community-residing individuals rt80 years-old have a gait disorder, and abnormal gait patterns are associated with a greater than two-fold increased risk of institutionalization and death in comparison to age-related adults without gait impa ...

Project Summary The goal of this Fast Track STTR project is to determine proof-of-principle and efficacy of a novel blood brain barrier (BBB) penetrating therapeutic nanoparticle for the potential treatment of otherwise intractable brain tumors like glioblastoma multiforme (GBM). This project seeks to demonstrate that novel, targetable nanoparticles can delivery therapeutic substances to human bra ...

Age-related hearing loss (ARHL) is the predominant neurodegenerative disease of aging. Recent animal studies have demonstrated that the earliest cochlear pathology due to noise and aging involves a loss of the inner hair cell ribbon synapse. The early consequences of this synaptic loss are not believed to affect hearing sensitivity, but rather, impair speech understanding in background noise. Whil ...

PROJECT SUMMARY Sarya LLC (Sarya) is a nuclear medicine technology company formed to commercialize radiopharmaceuticals. The goal of this Fast-Track STTR is to develop a new specific imaging agent for diagnosis, staging, and treatment of the hematological cancer, multiple myeloma (MM). MM is the 2nd most common blood cancer with an estimated 32,000 new cases and 13,000 deaths per year. Accurate de ...

This Phase I SBIR will lead to the development of a bandwidth tailored pump source for high purity photon pair generation. Spontaneous parametric down conversion can be used to generate high purity photon pairs at wavelengths of interest to NASA and the broader scientific community. However, these sources are highly dependent on pulsed pump laser parameters. Traditional pulsed laser sources are la ...

The overall goal of this NASA effort is to develop and deliver efficient, single-pass quantum optical waveguide sources generating high purity polarization entangled photon pairs for use in high-rate long-distance links. The key innovation in this effort is the use of efficient, low-loss spontaneous parametric down conversion (SPDC) waveguides in combination with apodized gratings to tailor the op ...

The overall goal of this NASA STTR mult-phase effort is to develop a compact fully integrated tunable narrowband bi-photon source operating in the visible/IR spectral region for calibration and characterization of high-performance transition-edge sensors (TES) arrays under development at NASA Goddard as well as other research facilities throughout U.S.nbsp; The key innovation in this effort is com ...

Quantum light sources are a critical need for NASA and the broader scientific community. The proposed program will develop ultra-high brightness, low loss, integrated quantum light sources in the IR spectral regime using waveguide-based technology.

Mitofusin agonists for the treatment of neurodegenerative diseases Gerald W Dorn II, MD Mitochondria in Motion, Inc. Washington University in St Louis School of Medicine Abstract: A number of rare neurodegenerative diseases are characterized by mitochondrial fragmentation, dysmotility and dysfunction. Among these are Amyotrophic Lateral Sclerosis (ALS) and Huntington’s Disease (HD), which cause ...