Award Data

DESCRIPTION (Provided by applicant): Although cell-based screening has been used successfully throughout the drug-discovery field, it is problematic when screening for antiviral compounds. This is because it requires inoculation of infectious virus onto the cells and the production of additional infectious progeny virus. Handling such infectious material is not easi ...

DESCRIPTION (provided by applicant): The goal of this proposal is to develop the commercial potential of a cell-based assay to screen for compounds with antiviral activity against filoviruses such as Ebola and Marburg viruses. The basis of this bioassay, which has been prototyped with respiratory syncytial virus, is infection-independent expression of a reporter gene from an artificial viral genom ...

DESCRIPTION (Provided by applicant): Hepatitis C virus (HCV) is the most prevalent chronic blood-borne infection in the U.S and a global health problem. Approximately 4 million individuals in the U.S. and 170 million individuals worldwide are chronically infected. As much as 40 percent of chronic liver disease is HCV related and this results in up to 10,000 deaths each year. Despite improvements, ...

DESCRIPTION (Provided by applicant): Hepatitis C virus (HCV) is the most prevalent chronic blood-borne infection in the U.S and a global health problem. Approximately 4 million individuals in the U.S. and 170 million individuals worldwide are chronically infected. As much as 40 percent of chronic liver disease is HCV related and this results in up to 10,000 deaths each year. Despite improvements, ...

DESCRIPTION (provided by applicant): The goal of the proposed research is to develop two prototype drug analyzers interfaced with automated analysis readers for low risk monitoring of illicit drug levels by Surface Enhanced Raman Immuno Assay (SERIA). The first prototype will be placed in a clinical setting. This study will include urine and saliva samples collected from clients of a juvenile ass ...

DESCRIPTION (provided by applicant): The goal of the proposed research is to develop two prototype drug analyzers interfaced with automated analysis readers for low risk monitoring of illicit drug levels by Surface Enhanced Raman Immuno Assay (SERIA). The first prototype will be placed in a clinical setting. This study will include urine and saliva samples collected from clients of a juvenile ass ...

DESCRIPTION (provided by applicant): The long terms goal of this research is the development of a portable instrument that will allow a relatively untrained operator to determine the presence and amount of up to twenty bioterrorism agents in a matter of fifteen to twenty minutes. The assay will be simple and very nearly immune to operator error. The principle application of the device will be for ...

DESCRIPTION (provided by applicant): CHA Corporation has developed a microwave-based air purification technology that can be effectively utilized to recover chemicals from soil vapors produced during hazardous site remediation without using a catalytic oxidizer. A field-ready prototype microwave treatment system will be designed, constructed, and tested in the laboratory during the first year of ...

DESCRIPTION (provided by applicant): The objective of the proposed research is to synthesize 4-hydroperoxyifosfamide (HOO-IFOS) in sufficient quantity for evaluation in vivo against a human osteosarcoma xenograft and additional tumor xenografts of breast, lung (small cell and non-small cell) and ovary cancers. A cyclophosphamide-resistant human melanoma xenograft will also be used in order to det ...

Infections by roundworm parasites, called nematodes, result in human mortality and morbidity, especially in subtropical and tropical regions of Africa, Asia, and the Americas. The World Health Organization estimates 2.9 billion people are infected. There are 595 known nematode parasites of vertebrates including hundreds that infect domesticated animals. Widespread use of drugs to control parasites ...