Award Data

DESCRIPTION (provided by applicant): This project will demonstrate a prototype microcontact printing aligner for use in ophthalmic tissue engineering. The performance of the microcontact printing aligner will be refined and validated by experiments conducted in collaboration with the Stanford Ophthalmic Tissue Engineering Laboratory. Functioning much like traditional rubber-stamping methods, micro ...

DESCRIPTION (provided by applicant): The goal of this project is to use an infection-independent cell-based assay to identify compounds that inhibit respiratory syncytial virus (RSV). The basis of this bioassay is expression of a reporter gene from an artificial viral genome present within the cytoplasm of transfected cells. Significant advances have been made in identifying the cis-acting elem ...

DESCRIPTION (provided by applicant): The goal of this project is to use an infection-independent cell-based assay to identify compounds that inhibit respiratory syncytial virus (RSV). The basis of this bioassay is expression of a reporter gene from an artificial viral genome present within the cytoplasm of transfected cells. Significant advances have been made in identifying the cis-acting elem ...

DESCRIPTION (provided by applicant): Respiratory syncytial virus (RSV) is the most important respiratory pathogen in infants, especially those born prematurely. It is also an important cause of disease in the elderly and immunosuppressed. There is no vaccine available to protect against RSV and "at risk" infants are presently treated by passive immunization. An effective small molecule drug that ...

DESCRIPTION (provided by applicant): The drug discovery industry is under increasing pressure to rapidly prioritize compound candidates based on their efficacy and specificity. Although traditional chip based gene expression microarrays can provide significant insights, sample format and throughput considerations preclude more widespread use. Microtiter plate based microarray (MPMA) systems can be ...

DESCRIPTION (provided by applicant): Somatostatin receptors are expressed on a number of tumor types including, neuroendocrine tumors, small cell lung carcinoma, and breast cancer. Commercial radiodiagnostic imaging agents targeted to this receptor are currently in clinical use, and corresponding radiotherapeutic agents are in clinical evaluation. While these therapeutic agents show much promise, ...

DESCRIPTION (provided by applicant): Coronary artery disease results in over one-half million deaths annually in the United States and is estimated to become the leading cause of death worldwide by the year 2020. Single Photon Emission Computed Tomography (SPECT) of the myocardium is a valuable clinical tool for the diagnosis and assessment of coronary artery disease usingT1-201 or Tc-99m-based ...

DESCRIPTION (provided by applicant): The goal of this Phase I STTR project is the development of an analytical method for the rapid detection of a variety of chemical warfare (CW) agents. A large number of methods have been used for the detection of CW agents, but they are generally not well suited for use under battlefield conditions, due to size, speed of analysis, power requirements or fragilit ...

DESCRIPTION (provided by applicant): The specific aim of this project is to develop a rapid test for the detection of cyanide in blood and saliva. Poisoning due to cyanide can occur vary rapidly in less than a few minutes, but current tests require at least 2 -3 hours for results to be reported. In rural communities, blood tests for cyanide are sent out for analysis and often several days pass be ...

DESCRIPTION (provided by applicant): The objective of this project is to develop a Windows-based software system that allows clinicians to apply advanced mathematical modeling capabilities to characterize myocardial mechanics. The prototype software developed during the Phase I project provides the framework for this development. The input required by the system consists of: (1) the digitized r ...