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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Expanding small molecule functional metagenomics through shuttle BAC expression i

    SBC: Intact Genomics Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Hospital acquired microbial infections are the fourth largest killer in America taking lives and adding $ B to hospital costs The emergence of drug resistant microbes has further amplified public health concern Fungi are prolific producers of anti microbial secondary metabolites SM and since the turn of the century have provided of bioactive m ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. MIST System for Simultaneous Parallel Intracellular Delivery & Transfection

    SBC: OPENCELL TECHNOLOGIES, INC.            Topic: 400

    DESCRIPTION provided by applicant Alternative nanomaterial and gene transfer solutions are needed to access the potential held in intracellular imaging biopharmaceuticals gene therapy and stem cell research Delivery of small and macromolecules including nucleic acids drug molecules imaging agents peptides antibodies and enzymes into cells is criti ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Anti-virulence FimH inhibitors for the treatment and prevention of UTIs

    SBC: FIMBRION THERAPEUTICS, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Over million women suffer from urinary tract infections UTI annually in the U S and approximately of these patients suffer from multiple recurrences UTI is unique in its high prevalence of chronic recurrent infections which has caused a tremendous need for long term conventional prophylactic therapy This is leading to increased antimicrobial res ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Experimental Design Software for Translational Gastrointestinal Microbiome Studie

    SBC: WILLIAM D SHANNON CONSULTING LLC            Topic: 300

    DESCRIPTION provided by applicant Design of experiments and test of hypotheses need to be available to research teams to develop and validate taxonomic metagenomic biomarkers in gastrointestinal tract GIT diseases The translational research team needs to design an experiment to test a hypothesis e g microbiota in Crohnandapos s disease is different than in normal controls calculat ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Rapid STEMI Fibrinolysis for Underserved Populations

    SBC: Pulse Therapeutics, Inc.            Topic: NIMHD

    DESCRIPTION provided by applicant Coronary heart disease CHD accounts for every of deaths in the United States US with acute incidences estimated at M annually Of these up to are classified as ST elevation myocardial infarction STEMI in which a clot blocks a coronary artery leading to a change in the ECG ST wave Because the heart muscle rapidly dies time to re ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Direct RT-PCR detection of RNA pathogens in crude samples

    SBC: DNA POLYMERASE TECHNOLOGY, INC.            Topic: 200

    DESCRIPTION provided by applicant The objective of this application is to introduce a novel simplified low cost technology to address the broad need of detecting RNA pathogens directly in crude samples such as blood Traditional RT PCR requires purifying the RNA which increases the cost time and risk of cross contamination We intend to reduce or eliminate the purification step by producin ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. A FLUOROMETRIC SENSOR FOR Cr(VI)

    SBC: MARKTEK INC            Topic: N/A

    Hexavalent chromium, Cr(VI), in the usual form of oxo species, is used in manyindustrial processes and products. As a consequence, Cr(VI)= containingcompounds are often found in wastewater and contaminated sites. Since Cr(VI) isconsidered highly toxic and carcinogenic, it is extremely important to have areliable, easy-to-use, sensitive monitor for determining Cr(VI) concentrationsin process, on ...

    SBIR Phase I 1995 Environmental Protection Agency
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