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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. New Assays for Expression Profiling of MicroRNAs

    SBC: Nawgen, LLC            Topic: 172

    DESCRIPTION provided by applicant MicroRNAs miRNAs are involved in many diverse biological processes and a single miRNA can modulate the expression of hundreds of gene targets Changes in miRNA expression could have profound biological impacts leading to a variety of human diseases To date most miRNA expression profiling studies have relied on microarrays or high throughput RNA sequencing ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. A Low Cost, Quantitative, Chemical Specific Device for Illicit Drug Detection

    SBC: MKS Technology            Topic: NIDA

    DESCRIPTION provided by applicant This proposal will assess the quantitative capabilities of surface enhanced Raman scattering SERS detection of cocaine and marijuana metabolites in urine samples Combining low cost instrumentation and novel chemical sensing provides an innovative new approach for diagnosing illicit drug use Current methods use a colorimetric indicator to screen specimens fo ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Activate Silent and Cryptic Intact Fungal SM Gene Clusters through FACs for Novel Antibiotics Discovery

    SBC: Intact Genomics Inc.            Topic: NIAID

    DESCRIPTION provided by applicant There is societal need for new therapeutic agents in our arsenal of defenses against bacterial and fungal pathogens many of which are increasingly resistant to existing antibiotics Filamentous fungi are considered promising resources for the development of novel bioactive compounds because of their great potential to produce various kinds of secondary metabol ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Optimized IL2-based Therapy for Type 1 Diabetes

    SBC: APT THERAPEUTICS, INC.            Topic: NIDDK

    DESCRIPTION provided by applicant Type diabetes is an immune mediated disease in which insulin producing beta cells are destroyed resulting in life long dependence on exogenous insulin The number of patients being diagnosed is increasing each year particularly in the very young Despite advances in glucose monitoring and insulin delivery there is a compelling need to identify therapies th ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Low-dose IL-2-based Immunomodulatory Therapy for PAH

    SBC: APT THERAPEUTICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant Despite evidence that inflammatory mechanisms initiate and complicate pathophysiology in pulmonary arterial hypertension PAH no strategies have been developed to target the inflammatory cells involved Moreover it has been known for years that autoimmune diseases are associated with certain forms of PAH Hence novel therapy is urgently needed to attenuate ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Electric field-assisted membranes for organic solvent nanofiltration

    SBC: THERMOSOLV LLC            Topic: 300

    DESCRIPTION provided by applicant This multi phase SBIR project targets a significant problem within the mission of the National Institute of General Medical Sciences rapid size based separation of small Da molecules in bio manufacturing The aim here is to simplify and radically improve this currently multi stage and a resource intensive process Manufacturing of active pharmaceut ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Cellular Capacitance Monitoring Integration into Digital Patch Clamp Amplifier.

    SBC: ROKHAN LLC            Topic: 105

    DESCRIPTION provided by applicant Cell membrane capacitance is directly proportional to cell surface area This is true because membrane composition thickness and dielectric constant are invariant and not changed by differences in membrane protein density It is thus possible to monitor cellular capacitance fluctuations as a measure of cell surface area changes that occur with exo and endo c ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Human Apyrase Therapy for Diabetic Neuropathic Pain

    SBC: APT THERAPEUTICS, INC.            Topic: NINDS

    DESCRIPTION provided by applicant Neuropathic pain such as diabetic neuropathic pain DNP can be difficult to treat with only of patients achieving meaningful andgt pain relief Current therapies e g duloxeline mainly address symptoms by focusing on blocking neurotransmission in the pain pathway with limited efficacy potentially severe side effects and narrow therapeutic in ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. An Ultra-fast Cooling Device for Vitrification and Cryopreservation of Cells and Tissues

    SBC: CRYOCRATE LLC            Topic: 300

    DESCRIPTION provided by applicant Storage and maintenance of valuable genotypes of animal model species as live animal lines would be wholly impractical However traditional cryopreservation techniques will be soon found to be inefficient for providing economic approach for cryopreservation of cells and tissues from millions of new animal models being developed Efficient cryopreservation of c ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Biomaterial augmented microfracture repair of full-thickness chondral defects04

    SBC: ISTO TECHNOLOGIES            Topic: NIAMS

    DESCRIPTION provided by applicant The goal of this project is to provide a synthetic biomaterial capable of giving long term repair of full thickness chondral lesions with the aim of helping to reduce the joint replacements carried out each year in the USA Our company has developed a synthetic biomaterial technology with proven biocompatibility in treating over patients for bon ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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