Award Data

This proposal aims to develop highly specific rapid and cost effective immunoassays to detect Zika virus ZIKV infection ZIKV is a single stranded RNA virus in the Flaviviridae family that is transmitted to humans through infected mosquitos blood transfusions and sexual contact As of June around Zika Virus disease cases have been estimated in Brazil alone Recently ZIKV has be ...

Abstract All therapeutic antibodies and most vaccines critically depend on the ability of antibodies to specifically recognize particular antigens consequently detailed characterization of antibody antigen binding can provide invaluable information to understand and guide development Unfortunately due to the time and expense required atomic resolution structure determination is typically use ...

Targeting the alternative pathway of complement to treat age related macular degeneration Abstract Age related macular degeneration AMD is the leading cause of vision loss in the developed world in people over and is a priority research area for the National Eye Institute It is a progressive degenerative disease that causes loss of the central vision due to destruction of the part of the re ...

PROJECT SUMMARY ABSTRACT There are infants born preterm each year in the United States alone Preterm infants often necessitate care in the neonatal intensive care unit One of the final milestones to be achieved in order to be discharged from the neonatal intensive care unit is oral feeding Oral feeding can be a challenge for infants born preterm as they do not have the maturity that all ...

Development of a DNA Aptamer Based Electrochemical Assay for Acetazolamide in Urine Using a Handheld Biosensor for Compliance Validation in Clinical Drug Trials Thirty to over eighty percent of patients enrolled in pharmaceutical clinical trials do not comply with trial protocols by discarding the drug under investigation or not using the proper dosages This common practice compromises the medica ...

PROJECT SUMMARY Pneumococcal pneumonia remains the leading cause of bacterial pneumonia in both children under years of age and adults over years of age The standard preventative therapy is the conjugate vaccine Prevnar which consists of an immunogenic carrier protein covalently attached to one of thirteen pneumococcal capsular polysaccharides Although Prevnar has significantly red ...

Overmillion women suffer from urinary tract infectionsUTIannually in the U Sandof these patients will suffer from recurrent infectionsincluding approximatelypatientsmostly womenwho will suffer from highly recurrentgreater thanepisodes per yearUTIAntimicrobial treatment of UTIs has resulted in increasing antimicrobial resistance among uropathogenic EcoliUPECto first line empiric therapiessuch as tr ...

Psoriasis is a devastating autoimmune disease that manifests itself in the form of patchy inflammatory skin lesions that can appear anywhere throughout the body resulting in tremendous physical pain and discomfort This chronic disease can also cause arthritic joints and have a profound impact on a patient s psychological well being In psoriatic lesions the detection of increased numbers of T c ...

PROJECT SUMMARY There is need for an artificial oxygen O carrier to substitute for banked blood in settings where stored blood is unavailable pre hospital care transport austere environments undeveloped countries or undesirable transfusion risk exceeds benefit To address this need we developed ErythroMer EM a first in class nano cyte blood substitute EM is a deformable ...

ABSTRACT TessaTM is validated medical device wearable capable of providing clinical sleep quality metrics for multiple nights to assess the efficacy of a sleep disorder treatment Tessa records the forehead EEG to stage sleep in an automated report that tracks changes in sleep architecture before and after a treatment for many sleep disorders such as obstructive sleep apnea and insomnia There is ...