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Award Data
The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.
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Novel sanitizer/disinfectants against viral infections with long-lasting effect
SBC: CAMELLIX, LLC Topic: NIAIDAbstractNorovirus is the most common cause of acute gastroenteritis in the United Statesassociated annually withmillion illnesseshospitalizations anddeathsUS CDCOverview about NorovirusNorovirus is one of the nonenveloped viruses that are resistant to alcohol sanitizationAccording to US CDC Guidelines for the Prevention and Control of Norovirus Gastroenteritis Outbreaks in Healthcare Settingsthe p ...
STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
The Diagnostic Utility of the in-vitro "Provoked" D dimer test in patients with suspected pulmonary embolism
SBC: AUGdimer LLC Topic: NHLBIProject SummaryThe D Dimer assay is the current diagnostic standard to exclude patients of VTE due to its high sensitivityHoweverD Dimer levels are commonly elevated in patients without thromboembolismleading to poor specificity and poor positive predictive valuePPVDue to the lack of a robust diagnostic tool for VTEwe propose a novel advancement upon current DDimer testing which improves specifici ...
STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Developing a Nutraceutical Product against Ototoxicity
SBC: GATEWAY BIOTECHNOLOGY, INC. Topic: NIDCDPROJECT SUMMARYDespite recent advances in cancer therapiesplatinum based drugs are still widely used for the treatment of solid tumorsA primary example is cisplatinwhich is frequently used to treat lungbladdertesticularand cervical cancersHoweverlimitations of this therapy include the development of drug resistance in cancer cells as well as severe side effectssuch as nephrotoxicity and neurotoxic ...
STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Biologically Targeted Vaccine for Chikungunya
SBC: PRECISION VIROLOGICS INC Topic: NIAIDPROJECT SUMMARY ABSTRACT Chikungunya virusCHIKVis a mosquito transmitted alphavirus that causes explosive epidemics of a severe febrile illness characterized by debilitating polyarthralgia in humansCHIKV caused an estimatedmillion new cases in India alone inand has the potential to spread globally because of the distribution and abundance of its mosquito vectorsAedes aegypti and Aedes albopictusDu ...
STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Mobile Peer Support for Opioid Use Disorders: Refinement of an Innovative Machine Learning Tool
SBC: Beacon Tech Inc. Topic: R41PROJECT SUMMARY This proposal develops a novelartificial intelligenceAIenabledmobile treatment delivery method that fulfills the need for a robustsecuretechnology based peer support platform to support patients with opioid use disordersOUDsThe majority of individuals with OUDs in the United States do not receive any formal substance use treatmentand growing evidence suggests that many OUD patients ...
STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
A Tissue Support Structure (Macular O-Rings) for Reconstructing, Translocating or Transplanting Three-Dimensional Submacular Tissue Organoids in Age Related Macular Degeneration (AMD)
SBC: iMacular Regeneration LLC Topic: NEIProject Summary Abstract Age related macular degenerationAMDis a leading form of irreversible blindnessiMacular Regeneration LLCiMac Regenwill introduce a novel tissue support structuremacular O rings or MORsmade from a biocompatibleimplantable materialnitinol or nickel titanium alloyThe surgical deviceMORwill be tested both ex vivo and in vivo for proof of concept in this phase I STTR studyThe de ...
STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health -
Developing a Small Peptide to Control Autoimmune Inflammation In Type 1 Diabetes
SBC: Op-T-Mune, Inc Topic: NIAIDTypeDiabetesT Daffects an ever growing populationWhile this disease typically has been associated with juvenilesthe disease in adult populations is rapidly increasingThe defining clinical component is insulin losswhich occurs because of sustained inflammation in the isletsAt present there is no means to prevent or reverse insulin lossA major inflammatory pathway in T D that contributes to insulin ...
STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Automated point-of-care identification of innocent Still's murmur in children
SBC: AUSCULTECH DX LLC Topic: NHLBIPROJECT SUMMARY The overall goal of the proposed research and technology transfer effort is to develop a low costpoint of caremobile device based technology for automated identification of Stillandapos s murmurthe most common innocentbenign and harmlessheart murmur of childhoodThis novel technology could reduce the current rate of over half a million children unnecessarily referred to pediatric ca ...
STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Oxidation-resistant Anti-protease Therapy
SBC: LEXEO Therapeutics LLC Topic: NHLBIAbstractLEXEO TherapeuticsLLCis an early stage biotechnology company focused on using gene therapy technologies to protect vulnerable organs from oxidant stressLEXthest LEXEO productis ast in classnext generation gene therapy treatment for alphaantitrypsinAATdeficiencyan autosomal recessive hereditary disorder associated with low serum levels of AATAATSERPINAakDa serine antiprotease produced by th ...
STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health -
Direct-read monitor for airborne viral pathogens
SBC: Aerosol Devices Inc. Topic: NIAIDAerosolized pathogenssuch as Influenza virusescan spread rapidly and silently throughout a populationcausing severe outbreaks that can be difficult to controlEarly detection of these airborne pathogens is key to controlling outbreaksespecially among vulnerable populations such as in hospitalstreatment centers or nursing homesYet available methods are neither rapidnor portableCurrent methods rely h ...
STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health