Award Data

DESCRIPTION Glycans have several distinct properties that make them excellent targets for disease biomarkers Firstly the location of the glycans on the cell surface makes them the first point of contact of cellular interactions and thus crucial in the control of normal metabolic processes Cell surface molecules are also strategically exposed for surveillance by the immune system allowing for ...

Decontamination of chemical and biological threats demands a very reactive solution. It is ideal to generate the decontaminants on-site: the activated decontaminant is highly reactive and quickly destroys chemical and biological warfare agents; prior to activation the ingredients can be safely stored for years, shipped, and handled. TDA's electrochemical decontamination (eClO2) technology u ...

Approximately 5-6% of military injuries involve some form of major peripheral nerve injury with little chance of spontaneous healing. Currently these injuries lead to major impairment of voluntary muscle function in the limbs and extremities, making tasks of walking, reaching, grasping, etc. very difficult or impossible for many patients. It is not enough to focus therapeutic treatment on the se ...

The Department of Defense and owners of large, commercial enterprise networks need excellent tools and well trained personnel to enforce cyber-security and counter cyber-attacks. This proposal focuses on supporting security personnel to have great Situational Awareness and training to help them use next generation cyber-security tools. In collaboration with University of Utah researchers with expe ...

The neurocognitive health of U.S. service members plays a vital role in the defense of the United States. It is critical to a service member"s effectiveness, to force readiness, and it is a key component of a service member"s successful reintegration into family life and society following deployment. Increased rates of mild traumatic brain injury (mTBI) and psychological health problems experien ...

In a low-texture indoor environment, landmark-based navigation is difficult due to lack of distinctive micro-features such as SIFT and SURF. Intelligent Automation, Inc. (IAI) and GRASP Laboratory at the University of Pennsylvania propose a Bio-Inspired Visual Navigation System with the following three innovations: First, we propose a segmentation-based method to extract landmarks as closed contou ...

DESCRIPTION (provided by applicant): In the last decade, Acinetobacter baumannii has emerged as one of the most highly antibiotic-resistant pathogens in the United States (US) and throughout the world. These infections are increasingly prevalent and highlylethal, killing 50-60% of those infected. Worse, strains of A. baumannii that no known antibiotic will kill have now emerged, and will continue ...

DESCRIPTION (provided by applicant): Up to 170 million people worldwide are chronically infected with HCV Hepatitis C virus (HCV) putting the infected individuals at significant risk for cirrhosis, liver failure and liver cancer. End- stage liver diseasecaused by HCV is the leading indication of liver transplantation (LT) in the United States. However, reinfection with HCV occurs universally and ...

DESCRIPTION (provided by applicant): Despite advances in the development of HIV drugs there remains a need for new therapies. Toxicities associated with long term use of many of the approved HIV drugs coupled with the development of resistance drives the need for new and novel antivirals. Maturation inhibitors (MIs) represent one such class of HIV therapies. HIV maturation inhibitors block virus r ...

DESCRIPTION: New therapeutic agents are urgently needed for the treatment of sickle cell disease (SCD), the world's most common genetic disease. Our long-term goal is to develop a drug for use in children that prevents the inexorable progression of SCD. SCD affects approximately 100,000 people in the United States and millions worldwide. It kills more children in Africa than HIV, but while HI ...