Award Data

Colloidal perovskite quantum dots (QDs) or nanocrystals (NCs) with structure of CsPbX3 (X = Cl, Br, I) are promising materials as down-converting phosphors due to their high quantum yield up to >90%, extremely narrow emission band ~15-30 nm, and tunable emission wavelengths of ~410−700 nm via size or composition control. Compared to other QD materials, the optical and electronic properties of pe ...

By 2025, 1.8 billion people will be living in places with severe water scarcity and two-thirds of the global population will encounter some degree of water stress. If warming continues at the current pace, by 2030 half of the world’s population will experience severe water stress (Runte 2016). The demands are strong; the restraints, on the other hand, come from (1) high capital investment for eq ...

Accurate simulation of nuclear power plant behavior is necessary for both engineering and training applications. An engineering grade simulator, used for design, safety analysis and operations, is characterized by high fidelity, computational power, lack of real-time capability, and user non-interactive environment. By contrast, a training grade simulator, used for operator training and education, ...

Increased productivity of wind turbines and wind plants requires a better understanding of the unsteady blade aerodynamics.This understanding could lead to improved energy capture and reduced blade loading and to a better understanding of wake development and propagation that promises to increase the overall production of a wind plant. Unsteady pressure measurements on the surface of the blades of ...

PROJECT SUMMARY Melanoma is one of the most prevalent cancers and is estimated to account for overdeaths inin the United States aloneAlthough highly curable when detected earlytheyear survival rates decline precipitously for patients with regionaland metastaticmelanoma indicating a lack of efficacy of conventional therapiesand a strong need for novel therapies for this patient populationIn respons ...

There is increasing interest in the use of biomarkers in clinical drug developmentwith much of thest Century Cures Act focused on encouraging this approachIdeallybiomarkers could provide and acute and objective read out of drug mechanism of actionpharmacodynamic biomarkersor prediction of later clinical benefit or harmsurrogate outcome measureHoweververy few biomarkers have been validated for rout ...

PROJECT SUMMARY Klebsiella pneumoniae is an increasingly prevalent drug resistant nosocomial pathogenCommonlyKpneumoniae isolates are carbapenem resistantwhich are referred to as carbapenem resistant EnterobacteriaceaeCREand present significantly less therapeutic intervention optionsFurthermorecommunity acquired infections associated with hypervirulent isolates of Kpneumoniae have emerged that are ...

Abstract Deep brain stimulationDBSwith implantable electrodes has been used for reduction of ethanol abuse and drug seeking behaviors in EuropeThe use of such deep brain stimulation procedures has been problematic because of concerns about invasiveness of the procedureApplicant has developed a new noninvasive method of transporting magnetic particles directly to target sites within the brainWe pro ...

Project SummaryThe objective of this supplementation request is to further our recent advances in the development of thewell Immuno CometChip assay results and build a prototypewell preformer giving the assay more utility and increasing commercial viability

Psychostimulant abuse is a significant public health problemwithmillion Americans reporting cocaine use andmillion reporting methamphetamine useCurrentlythere are no FDA approved pharmacotherapies to treat stimulant dependencePrevious cocaine medications development efforts have focused on small molecule drugs as they can readily enter the brainThe lack of brain penetrance by large molecules was s ...