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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Development of a vaccine to prevent Pneumocystis pneumonia

    SBC: NXT BIOLOGICS, INC.            Topic: NIAID

    Despite the fact that fungal diseases are an increasing clinical burden, particularly among immunocompromised patients, there are no anti-fungal vaccines approved for clinical use. The fungal opportunistic pathogen, Pneumocystis jirovecii is the causative agent of Pneumocystis pneumonia (PCP), which remains a serious AIDS-defining, opportunistic infection and is of increasing concern in persons re ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. The Diagnostic Utility of the in-vitro "Provoked" D dimer test in patients with suspected pulmonary embolism

    SBC: AUGdimer LLC            Topic: NHLBI

    Project SummaryThe D Dimer assay is the current diagnostic standard to exclude patients of VTE due to its high sensitivityHoweverD Dimer levels are commonly elevated in patients without thromboembolismleading to poor specificity and poor positive predictive valuePPVDue to the lack of a robust diagnostic tool for VTEwe propose a novel advancement upon current DDimer testing which improves specifici ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Developing a Nutraceutical Product against Ototoxicity

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    PROJECT SUMMARYDespite recent advances in cancer therapiesplatinum based drugs are still widely used for the treatment of solid tumorsA primary example is cisplatinwhich is frequently used to treat lungbladdertesticularand cervical cancersHoweverlimitations of this therapy include the development of drug resistance in cancer cells as well as severe side effectssuch as nephrotoxicity and neurotoxic ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Biologically Targeted Vaccine for Chikungunya

    SBC: PRECISION VIROLOGICS INC            Topic: NIAID

    PROJECT SUMMARY ABSTRACT Chikungunya virusCHIKVis a mosquito transmitted alphavirus that causes explosive epidemics of a severe febrile illness characterized by debilitating polyarthralgia in humansCHIKV caused an estimatedmillion new cases in India alone inand has the potential to spread globally because of the distribution and abundance of its mosquito vectorsAedes aegypti and Aedes albopictusDu ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. A Tissue Support Structure (Macular O-Rings) for Reconstructing, Translocating or Transplanting Three-Dimensional Submacular Tissue Organoids in Age Related Macular Degeneration (AMD)

    SBC: iMacular Regeneration LLC            Topic: NEI

    Project Summary Abstract Age related macular degenerationAMDis a leading form of irreversible blindnessiMacular Regeneration LLCiMac Regenwill introduce a novel tissue support structuremacular O rings or MORsmade from a biocompatibleimplantable materialnitinol or nickel titanium alloyThe surgical deviceMORwill be tested both ex vivo and in vivo for proof of concept in this phase I STTR studyThe de ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Prevention of type 1 diabetes using early glycation products

    SBC: HGG Research LLC            Topic: 200

    PROJECT SUMMARY TypediabetesT Da devastating and expensive organ specific autoimmune disease once afflicting mainly juvenilesis increasing in incidence among US adults withexcess risk of death in womenThe long term objective of this project is to develop a preventive and complementary strategy for T D management that is non invasivelong lastingand low costEarly glycation productsEGPsgenerated in t ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. HIGH RECOVERY RATE AND HIGH PURITY ENRICHMENT OF CIRCULATING TUMOR CELLS

    SBC: FCS Technology LLC            Topic: NIBIB

    Project Summary Abstract Circulating tumor cellsCTCsare cancer cells that are detached from primary solid tumors and carried through the vasculature to potentially seed distant site metastases in vital organsthe main cause of death by cancerSingle cell molecular characterizations and analyses of CTCs not only could benefit basic cancer researchbut also might eventually lead to a more effective can ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Use of mimotope vaccine technology to develop vaccines against bacterial pathogens

    SBC: ZenVax LLC            Topic: NIAID

    ABSTRACT This Small Business Technology TransferSTTRPhase I proposal is in response toNIH NIAID Research Topics in Division of Microbiology and Infectious Diseases and Bacteriology and Mycology BranchVaccine for prevention of human Q feverQ fever is a worldwide zoonotic disease that is caused by the obligate intracellular Gram negative bacteriumCoxiella burnetiiThe highly infectious nature of Cbur ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Microneedle Based Targeted Allergen Specific Immunotherapy for Treatment of Peanut Allergies

    SBC: Moonlight Therapeutics, Inc.            Topic: NIAID

    Microneedle Based Targeted Allergen Specific Immunotherapy for Treatment of Peanut Allergies Food allergies affectmillion people in the USA andmillion in EuropeSix million childrenroughlyinin the USA have at least one food allergythis equates to at leastin every classroomCurrentlythere are no approved therapies for food allergies anywhere in the worldFood allergies are expected to growannually unt ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Pulmonary valved conduit xenograft with regeneration potential

    SBC: TGen Tech, LLC            Topic: NHLBI

    Congenital heart disease affects approximatelynewborns each year in the U SValve and conduit replacements are needed for absent pulmonary valveaortic stenosisKonno procedureRoss proceduredouble outlet right ventricleRastelli operationextracardiac conduitFontan operationpulmonary valve replacementTetralogy of FallotMaterials in current use include homograft blood vesselsglutaraldehyde treated bovin ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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