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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Glycoengineering a bioconjugate vaccine against Klebsiella pneumoniae

    SBC: VaxNewMO            Topic: NIAID

    PROJECT SUMMARY Klebsiella pneumoniae is an increasingly prevalent drug resistant nosocomial pathogenCommonlyKpneumoniae isolates are carbapenem resistantwhich are referred to as carbapenem resistant EnterobacteriaceaeCREand present significantly less therapeutic intervention optionsFurthermorecommunity acquired infections associated with hypervirulent isolates of Kpneumoniae have emerged that are ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Development of Fibrin-Specific Nuclear Probe to Reduce LVAD Adverse Events

    SBC: CAPELLA IMAGING, LLC            Topic: NHLBI

    Despite the myriad major advances in cardiologythe prognosis for patients with severemedically refractive heart failureHFis exceedingly poorApproximatelydeaths occur annually in patients with HF who have endured an impaired quality of life often accompanied by significant economic and personal losses due to recurrent hospitalizationsAt leastof these deaths were directly related to severe heart fai ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. ErythroMer: Nanoscale Bio-Synthetic Red Cell Substitute

    SBC: KaloCyte Inc            Topic: NHLBI

    PROJECT SUMMARY There is need for an artificial oxygenOcarrier to substitute for banked blood in settings wherestored blood is unavailablepre hospital care transportaustere environmentsundeveloped countriesorundesirabletransfusion risk exceeds benefitTo address this needwe developedErythroMerEMa first inclass nano cyte blood substituteEM is a deformablecross linked polymeric nanoparticle that inco ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. An unique patient population for clinical trials against noise-induced hearing loss

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    AbstractNoise is the number one occupational and environmental hazardand noiseinduced hearing lossNIHLis one common form of sensorineural hearing deficitonly second to age related hearing lossCurrently no drug preventing NIHL is approved by the United States Food and Drug AdministrationFDAOne major challenge for the introduction of such interventions is the need to identify appropriate human popul ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Smart Sensor Bandage for Ulcer Monitoring

    SBC: STOECKER MD, WILLIAM V            Topic: 600

    AbstractSmart Sensor Bandage for Ulcer Monitoring Non healing pressure ulcers result in approximately $billion in additional treatments each year in the United Statesraising in hospital mortality by nearly threefold and lengthening hospital stay by more than double when ulcers are presentThis burden is particularly pronounced in assisted living facilities where occurrence is high and skilled nursi ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Develop novel lutein biomanufacturing in a nonmodel yeast via engineered metabolons and metabolic analyses

    SBC: Arch Innotek, LLC            Topic: 300

    Project Summary Arch Innotek proposes to develop a sustainablecost effective fermentation process to produce lutein using engineered yeastLutein is an important antioxidant compound that can slow the progression of vision loss caused by age related macular degenerationAMDcataractsand retinitis pigmentosaAside from protecting eyesdietary intake of lutein can reduce risk of skin disordersseveral typ ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. A Deep Learning Model to Improve Pathologist Interpretation of Donor Kidney Biopsies

    SBC: PlatformSTL (DBA for NewVentureIQ LLC)            Topic: 300

    PROJECT SUMMARY ABSTRACT More people die every year from kidney disease than breast or prostate cancerKidney transplantation is life saving but is limited by a shortage of organ donors and an unacceptably high donor organ discard rateThe decision to use or discard a donor kidney relies heavily on manual quantitation of key microscopic findings by pathologistsA major limitation of this microscopic ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Novel Tetrahedron Beam CT for Point-of-Care Imaging in Ear, Nose, and Throat

    SBC: TetraImaging LLC            Topic: NIBIB

    ABSTRACT Point of care imaging is highly desired in otolaryngologic clinics for the diagnosis of earnose and throatENTdiseases including cancersDue to limited image qualitycurrent cone beam CTCBCTproducts act not as a substitute but rather as a complement to diagnostic Multi slice CTMSCTin maxillofacial and ENT imagingThe emerging multi source x ray source technology suggests new designs of CT sys ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. A New Small-Molecule Kinase Inhibitor for Breast Cancer

    SBC: NuPeak Therapeutics, Inc.            Topic: 102

    NuPeak Therapeutics Incis a biotechnology start up companyC corporationdesigned to deliver a first inclass small molecule kinase inhibitorThe present Project is aimed at an inhibitor for treatment of breast cancerwhich remains a leading cause of morbidity and mortality in the U Sdespite current therapeutic approachesIn that contextwe identified a novel typeimmune response that activates mitogen ac ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Quantitative Handwriting Assessment Tool for Healthy and Impaired Children

    SBC: PlatformSTL (DBA for NewVentureIQ LLC)            Topic: NICHD

    No technology currently exists for objective assessment of handwritingeven though overmillion individuals in the United States suffer from disorders that affect handwritingincludingmillion children with dyspraxia and overolder adults with Parkinsonandapos s diseaseThis lack of assessment technology creates a barrier to effective carebecause occupational therapists cannot easily distinguish motor d ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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