Award Data

PROJECT SUMMARY/ABSTRACT In response to National Institute on Aging's (NIA) strategic plan and PAS-19-317, we propose novel therapeuticsto treat Alzheimer disease and related dementias (ADRDs). We have developed novel combinations of three natural product compounds, which modulate complementary pathways in multiple types of CNS cells (i.e., neurons, microglia) associated with AD pathology. These c ...

PROJECT SUMMARY Actively involving informal caregivers in direct patient care at the bedside in the intensive care unit (ICU) has the potential to improve patient, informal caregiver, and health care system outcomes. Practice guidelines call for the liberal inclusion of informal caregivers as active partners in ICU care, but there is a critical, unmet need to develop tools that effectively operati ...

Project Summary/Abstract Stroke is the leading cause of serious long-term disability and accounts for 4.6 million disabled people in the United States. Stroke-related costs total over $46 billion in the United States each year.1 Of the nearly 800,000 Americans who have a stroke per year, 87% experience ischemic stroke1, of which 49%-86% are attributed to either large vessel occlusions (LVO) or med ...

The proposed phase-I STTR research is an interdisciplinary effort to develop more effective clinical management of Status Epilepticus (SE) in collaboration with one of the leading neurological institutes in the world, the Barrow Neurological Institute in Phoenix, Arizona. SE is a life-threatening neurological emergency that can occur without warning and is characterized by recurrent seizures witho ...

There is a need for a lightweight, high-performance, insulation to protect the internal systems in hypersonic vehicles. A passive thermal protection system (TPS) design would be simple and reliable. As designs evolve, there is a need for TPS insulation materials that can be additively manufactured. Our Phase I approach will additively manufacture pre-ceramic scaffolds that are used to create low d ...

We propose to develop Para-DEVS, an extension of the existing modeling and simulation (M&S) environment overcome two major hurdles that must be overcome to implement paratemporal simulation techniques for application to execution of large stochastic models. We propose to develop techniques to achieve scalability, the ability to overcome the combinatorial explosion of branching arising from multipl ...

In the proposed effort, we will develop the fundamental building blocks to develop a high performance, low Size, Weight, and Power (SWaP) ultrashort pulse Femtosecond Direct Diode Laser System (fsDDLS) capable of generating and sustaining filaments/plasma channels in the atmosphere ahead of a vehicle in hypersonic flight to reduce drag, heating, and displace shock. Approved for Public Release | 22 ...

The current state-of-the-art radiation detection materials have different drawbacks limiting their applications in the next-generation mobile radiation detection system. NP Photonics proposes to develop a novel scintillating glass that can be used to make large form-factor scintillators for nuclear battlefield operations. The proposed scintillating glass has the advantages of low cost, short decay ...

Alphacore and Vanderbilt University will develop innovative, cost effective methodology and solutions for radiation testing of microelectronics, to evaluate and distinguish between radiation effects from a persistent beta environment and a persistent gamma environment, and determine the circumstances where testing for one environment is sufficient to show survivability in the other, or in a combin ...

PROJECT ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and fatal fibrotic lung disorder which disproportionately affects men and the elderly. Although two drugs (pirfenidone and nintedanib) have recently gained FDA-approval for IPF and progressive fibrosing lung disorders related to connective tissue diseases (rheumatoid arthritis and scleroderma, more common in younger ...