Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. A novel vaccine against mosquito-borne Zika virus based on mosquito salivary gland protein AgBR1

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    PROJECT SUMMARYZika virusan emerging flavivirusis associated with severe clinical outcomesincluding Guillain Barrsyndrome and birth defectsTransmission of Zika virus is primarily mosquitoborneMosquito salivary proteins are known to enhance infectivity and pathogenesis in Zikadengue and West Nile viruses by modulating immune responsesThis proposal seeks to develop a novel vaccine against Zika virus ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a Personalized Bioreactor for Cell Culturing in Alginate Tubes

    SBC: CellGro Technologies, LLC            Topic: 400

    PROJECT SUMMARY ABSTRACT SignificanceCell therapy is expected to become an important method to treat chronic diseases such as diabetesrheumatoid arthritisretinal diseases like macular degeneration and certain types of cancersThe cell therapy market in general is projected to become a $billion industry byHuman pluripotent stem cellshPSCsare of particular importance since their utility as a source f ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Additive Manufactured PEKK Implants for Small Bone Arthroplasty

    SBC: Oxford Performance Materials, Inc.            Topic: NIAMS

    ABSTRACT This Phase I STTR is designed to evaluate the feasibility of using the OsteoFabtechnology platform for joint arthroplastyArthroFabdevicesspecifically targeting replacement of the small carpal bones in the wrist and hemiarthroplastyOsteoFabtechnology is the combination of Oxford Performance Materialsandaposproprietary formulation of polyetherketoneketoneOXPEKKpolymerand additive manufactur ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Targets of Acquired Tick-Resistance As Anti-Tick Vaccines

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    ABSTRACTThis proposal seeks to develop a novel vaccine against pathogens transmitted by the blacklegged tickIxodes scapularisby targeting tick salivary proteinsSalpscritical for tick feedingIscapularis Salps provide functions critical for evading host defense responses detrimental to the tickFurtherthese salivary functions are also co opted by tick transmitted pathogens to ensure their survival in ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Nanoparticle-based Intraperitoneal Delivery of Combined Chemo-brachytherapy for Treatment of Ovarian Cancer Metastases

    SBC: Nami Therapeutics Corp.            Topic: 102

    PROJECT SUMMARY ABSTRACT Ovarian cancer is the second most common gynecologic cancer in the United States and the most common cause of death among women with gynecologic malignanciesDespite advances in treatment strategiesperitoneal metastasis remains the primary cause of morbidity and mortality in ovarian cancerThe National Cancer Research Institute Clinical and Translational Radiotherapy Researc ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Immunization with mosquito AgTRIO protein to prevent malaria

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    PROJECT SUMMARYMalaria is one of the world s major public health threatsThe disease is transmitted when an infected female Anopheles mosquitowhile probing for a blood mealinjects saliva together with Plasmodium sporozoites into the skin of the vertebrate hostTo datea highly effectivesafe and FDA approved human vaccine against malaria has not been developedThe most established malaria vaccine candi ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A novel approach to treat non alcoholic steatohepatitis NASH

    SBC: Mitotherapeutix LLC            Topic: 300

    Abstract The Specific Aim of this Phase I STTR proposal is to test the feasibility of treating non alcohol steatohepatitis NASH by increasing mitochondrial metabolism which is the main pathway for lipid catabolism in the liver NASH is a stage of non alcohol fatty liver disease NAFLD that has progressed to a pathological state NASH can lead to cirrhosis leading to liver failure or hepatocel ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Engineering a phosphotyrosyl-tRNA Synthetase

    SBC: AXIOMX INC            Topic: 300

    DESCRIPTION provided by applicant Although tyrosine phosphorylation is an important controlling element in cell signaling no tRNA suppressor for phosphotyrosine pTyr incorporation has yet been made We propose to use directed molecular evolution of several aminoacyl tRNA synthetases aaRSs to identify mutations that enable binding of pTyr to the aaRS Specifically ATP molecules will be att ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Measuring toxicant effects on cellular function in a microarray format

    SBC: CIENCIA INC            Topic: NIEHS

    DESCRIPTION provided by applicant The EPA maintains a Toxics Release Inventory of over toxic chemicals that are disposed or released from more than industrial sites in the United States The Department of Health and Human Services and USDA maintain a list of over select agents and toxins that pose a severe risk to both human animal and plant health These compounds represent only ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Production of Chemical Reagents for Prompt-Agent-Defeat Weapons

    SBC: NALAS ENGINEERING SERVICES INC            Topic: DTRA14B001

    The US DoD requires robust ways of neutralizing threats posed by hostile powers and terrorist organizations that may be in possession of dangerous weapons of mass destruction (WMDs). Unfortunately, the weapons currently available to the DoD do not offer a way for the WMD to be destroyed without risking the spread of that material throughout the area. The strategy for the defeat of biological weapo ...

    STTR Phase I 2015 Department of DefenseDefense Threat Reduction Agency
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