Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. The Diagnostic Utility of the in-vitro "Provoked" D dimer test in patients with suspected pulmonary embolism

    SBC: AUGdimer LLC            Topic: NHLBI

    Project SummaryThe D Dimer assay is the current diagnostic standard to exclude patients of VTE due to its high sensitivityHoweverD Dimer levels are commonly elevated in patients without thromboembolismleading to poor specificity and poor positive predictive valuePPVDue to the lack of a robust diagnostic tool for VTEwe propose a novel advancement upon current DDimer testing which improves specifici ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A Tissue Support Structure (Macular O-Rings) for Reconstructing, Translocating or Transplanting Three-Dimensional Submacular Tissue Organoids in Age Related Macular Degeneration (AMD)

    SBC: iMacular Regeneration LLC            Topic: NEI

    Project Summary Abstract Age related macular degenerationAMDis a leading form of irreversible blindnessiMacular Regeneration LLCiMac Regenwill introduce a novel tissue support structuremacular O rings or MORsmade from a biocompatibleimplantable materialnitinol or nickel titanium alloyThe surgical deviceMORwill be tested both ex vivo and in vivo for proof of concept in this phase I STTR studyThe de ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Prevention of type 1 diabetes using early glycation products

    SBC: HGG Research LLC            Topic: 200

    PROJECT SUMMARY TypediabetesT Da devastating and expensive organ specific autoimmune disease once afflicting mainly juvenilesis increasing in incidence among US adults withexcess risk of death in womenThe long term objective of this project is to develop a preventive and complementary strategy for T D management that is non invasivelong lastingand low costEarly glycation productsEGPsgenerated in t ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. HIGH RECOVERY RATE AND HIGH PURITY ENRICHMENT OF CIRCULATING TUMOR CELLS

    SBC: FCS Technology LLC            Topic: NIBIB

    Project Summary Abstract Circulating tumor cellsCTCsare cancer cells that are detached from primary solid tumors and carried through the vasculature to potentially seed distant site metastases in vital organsthe main cause of death by cancerSingle cell molecular characterizations and analyses of CTCs not only could benefit basic cancer researchbut also might eventually lead to a more effective can ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Microneedle Based Targeted Allergen Specific Immunotherapy for Treatment of Peanut Allergies

    SBC: Moonlight Therapeutics, Inc.            Topic: NIAID

    Microneedle Based Targeted Allergen Specific Immunotherapy for Treatment of Peanut Allergies Food allergies affectmillion people in the USA andmillion in EuropeSix million childrenroughlyinin the USA have at least one food allergythis equates to at leastin every classroomCurrentlythere are no approved therapies for food allergies anywhere in the worldFood allergies are expected to growannually unt ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Pulmonary valved conduit xenograft with regeneration potential

    SBC: TGen Tech, LLC            Topic: NHLBI

    Congenital heart disease affects approximatelynewborns each year in the U SValve and conduit replacements are needed for absent pulmonary valveaortic stenosisKonno procedureRoss proceduredouble outlet right ventricleRastelli operationextracardiac conduitFontan operationpulmonary valve replacementTetralogy of FallotMaterials in current use include homograft blood vesselsglutaraldehyde treated bovin ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a Personalized Bioreactor for Cell Culturing in Alginate Tubes

    SBC: CellGro Technologies, LLC            Topic: 400

    PROJECT SUMMARY ABSTRACT SignificanceCell therapy is expected to become an important method to treat chronic diseases such as diabetesrheumatoid arthritisretinal diseases like macular degeneration and certain types of cancersThe cell therapy market in general is projected to become a $billion industry byHuman pluripotent stem cellshPSCsare of particular importance since their utility as a source f ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Detection of HIV proteins in urine to diagnose infection

    SBC: Newmark Diagnostics LLC            Topic: NIMH

    PROJECT SUMMARY ABSTRACT The development of a low costpoint of care diagnostic device or kit in arapid testorself testformat would be highly beneficial to the global effort to diagnosemanage and treat HIVWe are proposing to evaluate the scientific finding that HIV proteins are present in urine associated with extracellular vesiclesalso commonly referred to as exosomesThe development of one or more ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Novel sanitizer against viral infections with long lasting effect

    SBC: CAMELLIX, LLC            Topic: NIAID

    Project Summary Abstract Despite mandatory use of hand sanitizer on cruise ships there are reported cruise ship onboard norovirus outbreaks in exceeded the number of norovirus outbreaks outbreaks onboard cruise ships in One of the problems of currently available alcohol based hand sanitizer is that alcohol evaporates in less than seconds after each application to a surface ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Anti CCL mAb to treat castration resistant prostate cancer

    SBC: JYANT Technologies, Inc.            Topic: 102

    Metastatic castration resistant prostate cancer CRPC PCa accounts for of PCa deaths and is associated with skeletal metastases CRPC affects patients differently making this disease difficult for physicians to provide standardized treatments with similar outcomes Docetaxel can prolong the overall survival in patients with metastatic CRPC but current therapies do not provide a cure Doce ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
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