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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Development of a vaccine to prevent Pneumocystis pneumonia

    SBC: NXT BIOLOGICS, INC.            Topic: NIAID

    Despite the fact that fungal diseases are an increasing clinical burden, particularly among immunocompromised patients, there are no anti-fungal vaccines approved for clinical use. The fungal opportunistic pathogen, Pneumocystis jirovecii is the causative agent of Pneumocystis pneumonia (PCP), which remains a serious AIDS-defining, opportunistic infection and is of increasing concern in persons re ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Feasibility Study of HIF2A Inhibitor PT2385 to Treat Muscle Strain Injury

    SBC: HAWA Therapeutics LLC            Topic: OD

    ABSTRACT Multi-PIs: Yin, A (HAWA Therapeutics) and Yin, H (UGA) Muscle strain injury (also called pulled muscle or eccentric contraction-induced muscle injury) is a common health problem affecting everyone in daily life. A mildly strained muscle may recover completely within one to two weeks; whereas moderate-to-severe muscle strains usually result in a prolonged and incomplete recovery with persi ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Multi NA-based influenza vaccines

    SBC: ADVAC LLC            Topic: NIAID

    PROJECT SUMMARY Current influenza (flu) vaccination inducing strain-specific immunity against variable hemagglutinin (HA) proteins is suboptimal for providing cross protection against antigenically-different epidemic strains and unanticipated new pandemic viruses. Development of an effective flu vaccine inducing enhanced cross protection against viruses with different HA variants is a high priorit ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Decellularized xenograft leaflet patch for pulmonary valve repair in pediatric patients

    SBC: TGen Tech, LLC            Topic: NIBIB

    Congenital heart disease affects approximately 40,000 newborns each year in the U.S. Valve repairs are needed for pulmonary valve, particularly for patients with the diagnoses of tetralogy of Fallot, tetralogy of Fallot with absent pulmonary valve, tetralogy of Fallot with AV canal, pulmonary valvar stenosis, and pulmonary valvar atresia. An additional group are patients with a prior repair of tet ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Nanoparticles for detecting noradrenergic neurons in Alzheimer's Disease

    SBC: S G ENDOCRINE RESEARCH LLC            Topic: NIA

    Summary: Alzheimerandapos;s disease (AD) is a progressive neurological disorder that is marked by the presence of amyloid-ß plaques, neurofibrillary tangles and cognitive deficits. The economic impact of this disease is staggering and is expected to exceed $1 trillion dollars by the year 2050. Early diagnosis and treatment can substantially reduce the economic burden related to AD. Specifically, ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Antioxidant enzyme-loaded Pro-NP for treatment of TBI.

    SBC: ProTransit Nanotherapy, LLC            Topic: 106

    ABSTRACT Traumatic brain injury (TBI) is one of the leading causes of death and disability worldwide and comes with a significant economic burden associated with emergency room visits and hospitalizations. Oxidative stress- mediated secondary injury post-TBI is a considerable risk factor for mortality and long-term impairment. Immediately following TBI, a cascade of biological responses leads to i ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. An Economical Point-of-Care Software Solution Prototype for Medication Prior Authorization

    SBC: Breezmed            Topic: 104

    ABSTRACT This STTR Phase I project uses mixed-method formative evaluation strategies to develop, test, and evaluate an alpha prototype of Breezmed, a point-of-care electronic prior authorization web-based platform. Prior authorization burdens the current medical system, hampering a provider’s ability to efficiently prescribe medication and in a timely fashion. This often leads to treatment non-c ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Isotopically Labeled Heparan Sulfate Glycosaminoglycan Disaccharides for use as Internal Standards

    SBC: GlycoScientific, L.L.C.            Topic: 300

    PROJECT SUMMARY/ABSTRACTSulfated glycosaminoglycan (GAG) carbohydrates represent one of the more structurally diverse groups of biomolecules, and a comprehensive understanding of their biological structure-function relationships has yet to be achieved. Unlike other biomolecules such as DNA/RNA and proteins that are synthesized based upon a template, GAG biosynthesis is the result of the cumulative ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Serum Detection of Medulloblastoma Metastasis

    SBC: 5M BIOMED, LLC            Topic: 102

    PROJECT SUMMARY Medulloblastoma (MB) is the most common form of primitive neuroectodermal tumor of the pediatric central nervous system (CNS). The standard treatment of MBs includes surgical resection, followed by chemo- or radiation treatments. Dissemination of cancer cells and subsequent metastasis is one of the major causes of treatment failure. Early identification of MB metastases is importan ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a Lighted Infusion Line to Enhance Pediatric Critical Care

    SBC: CHS Healthcare Ventures, Inc            Topic: NICHD

    PROJECT SUMMARY Patients in the intensive care unit (ICU) represent the most critical of patients and admissions into the ICU are significantly increasing, thus creating a growing demand on critical care nurses that care for these patients. ICU nurses experience heightened workload, which can lead to missed nursing care, increased medical error. Nursing management of intravenous tubes and componen ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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