Award Data

DESCRIPTION (provided by applicant): Acid-prepared mesoporous silica ("APMS") shows significant advances over commercially available silica in high performance liquid chromatography ("HPLC"), a technique commonly used to isolate molecules. HPLC columns containing APMS show dramatically enhanced molecular retention times and improved peak-to-peak resolutions compared to commercial HPLC columns. The ...

DESCRIPTION (provided by applicant): Our research is focused on the potential of acid-prepared mesoporous silica (APMS) as a delivery agent for siRNA constructs to inhibit the ERK1/2 and ERK5 pathways in the treatment of human malignant mesothelioma (MM). These pathways are critical to MM cell proliferation and chemoresistance. Our initial research suggests that APMS will be significantly more eff ...

DESCRIPTION (provided by applicant): The overall objective of the proposed cooperative research and development project is the implementation and validation of an advanced instrument tracking technology to be used by the surgeon, the radiologist, the gastroenterologist, and other physicians to better enable image-guided cancer treatment, through these specific aims: Specific aim 1: Ascension ...

DESCRIPTION:(provided by applicant) The goal of this project is to develop a novel inhibitor of methane formation in ruminant animals. Currently, monensin, a relatively nonspecific antibiotic, is widely used in the livestock industry. Monensin increases agricultural productivity by decreasing methane and increasing propionate production; however, it also inhibits ...

DESCRIPTION (provided by applicant): Although the vast majority of patients who suffer from venous or arterial thrombosis have haemostatic systems that fall within the "normal" range of routine screening tools such as PT, aPTT, and factor assays, thrombosis is the major cause of death in Western countries. In contrast, the propensity to bleed (i.e., hemophilia) is more easily diagnosed by traditio ...

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The partial opioid agonist buprenorphine, is expected to be approved by the FDA in the very near future for the treatment of opioid-dependence and will be available via physician prescription, enabling a greatly needed expansion of access to opioid treatment services. However, physicians, because of considerable dema ...

DESCRIPTION (provided by investigator): Recent evidence indicates that drug use is highly prevalent among children and adolescents, and initiation of drug use is often occurring at very early ages. These findings underscore the need to initiate age appropriate prevention efforts with youth at an early age in elementary school and continue these interventions throughout middle school and later ye ...

DESCRIPTION (provided by applicant): The partial opioid agonist buprenorphine, is expected to be approved by the FDA in the very near future for the treatment of opioid-dependence and will be available via physician prescription, enabling a greatly needed expansion of access to opioid treatment services. However, physicians, because of considerable demands on their time, will likely be unable to p ...

DESCRIPTION (provided by applicant): The primary objective of this Phase I STTR project is to develop an effective, peptide-based nicotine vaccine for use in humans capable of inducing a robust, nicotine-specific antibody (Ab) response with little or no inflammatory side effects. This will be accomplished by a vaccine design in which a conformationally biased, response-selective agonist Of C5a ( ...