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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. ICU-CARE: An interactive mobile app to enhance the efficiency of daily informal caregiving in the intensive care unit

    SBC: SILICON CURES LLC            Topic: NINR

    PROJECT SUMMARY Actively involving informal caregivers in direct patient care at the bedside in the intensive care unit (ICU) has the potential to improve patient, informal caregiver, and health care system outcomes. Practice guidelines call for the liberal inclusion of informal caregivers as active partners in ICU care, but there is a critical, unmet need to develop tools that effectively operati ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Targeting Myosin to Treat Polycystic Kidney Disease

    SBC: PLUREXA LLC            Topic: 400

    PROJECT SUMMARY The goal of this proposal is to advance a new therapeutic approach targeting myosin for polycystic kidney disease (PKD). PKD is a major life-threatening Mendelian disorder that affects 12,000,000 individuals, representing a market opportunity of ~$1 billion. In PKD, tiny tubules in the kidneys, liver, and other organs gradually expand into fluid-filled cysts, leading to organ failu ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Dialysate regeneration system based on photo-electrochemical urea oxidation and reactive adsorption to enable portable hemodialysis

    SBC: KULEANA TECHNOLOGY, INC.            Topic: 400

    PROJECT SUMMARY/ ABSTRACT Currently in the US there are over 400,000 kidney patients on dialysis. The primary therapy mode is hemodialysis and is performed in a hospital or private clinic. Current dialysis therapy requires a large device that must be continuously connected to a reverse osmosis (RO) system. A single treatment will require over 150L of AAMI dialysate making portable device unattaina ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Novel diagnostic biomarker reference standards for newborn screening of Mucopolysaccharidoses type I and II.

    SBC: GELBCHEM, LLC            Topic: NICHD

    Project Summary The goal of this project is to design and prepare diagnostic biomarker reference standards for the endogenous glycosaminoglycan (GAG) Mucopolysaccharidosis type I (MPS-I) and type II (MPS- II) biomarkers. MPS-I and MPS-II are lysosomal storage disorders (LSDs) which are listed on the Recommended Uniform Screening Panel (RUSP) in the United States and are included in global Newborn ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Real-Time Quantitation of Transport Across Vascular-Tissue Interfaces in Organ-On-Chip Models Using In Situ Mass Spectrometry

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Abstract Current in vitro platforms are poor predictors of the in vivo safety, efficacy and pharmacokinetics of therapeutics, owing to a significant difference in the test conditions compared to physiological conditions. Therefore, drug toxicity testing is routinely performed using animal models. However, animal testing is expensive and time consuming. In addition, ethical concerns about the use o ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Simultaneous pharmacological profiling of oncogenic gene fusion proteins in cancer

    SBC: TALUS BIOSCIENCE INC            Topic: 393

    RESEARCH SUMMARY The human genome encodes more than 1,600 transcription factors (TFs), along with additional cofactors, chromatin regulators, and structural proteins that collectively execute the regulatory instructions encoded within the nuclear DNA. Dysfunctions of these proteins, collectively known as Gene Regulatory Proteins (GRPs), are known to drive multiple diseases such as cancer, inflamma ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Development of Novel CD180-Based Cancer Immunotherapeutics

    SBC: ABACUS BIOSCIENCE INC            Topic: NCI

    Program Director/Principal Investigator (Last, First, Middle): Clark, Edward A PROJECT SUMMARY Abacus Bioscience focuses on developing novel and game changing immunotherapies for treating cancers and chronic infectious diseases. We have developed a broad-based, patented, platform technology that can plug-and-play with multiple cancer or viral antigens (Ags). We propose to establish a new class of ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. A tandem mass spectrometry diagnostic test for newborn screening of Tay-Sachs and Sandhoff diseases

    SBC: GELBCHEM, LLC            Topic: NICHD

    Summary The goal of this project is to develop a tandem mass spectrometry assay for newborn screening of GM2-gangliosidosis for which several treatment options are being developed. GM2- gangliosidosis includes Tay-Sachs and Sandhoff diseases, inherited metabolic disorders which cause a progressive deterioration of nerve cells. Tay-Sachs disease is caused by HexA enzyme deficiency and Sandhoff dise ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Scalable, non-dissociative single-cell RNA sequencing for mapping the brain in health and disease

    SBC: TOPOGENE, INC.            Topic: NIMH

    ABSTRACT A fundamental goal of the BRAIN Initiative and other neuroscience projects is to map cell types in the brain and study their changes associated with function, disease, and drug treatment. An important avenue toward it is to spatially analyze transcriptome of individual cells in morphologically intact tissues. However, despite recent advances of imaging and omics technologies, brain mappin ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Multispectral Sensor for Chemical Composition Analysis of Ultrafine Aerosols in Air Quality Assessment

    SBC: SPECTREE INC.            Topic: 143

    Project SummaryWe propose developing and validating a novel platform technology that combines the collection and chemical analysis of ultrafine particles using an in-situ multispectral technique. The sample, collected directly onto the analysis substrate, is analyzed via excitation-emission matrix (EEM) spectroscopy. This approach will be validated against laboratory combustion-generated aerosols, ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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