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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Accelerated x-ray therapy planning system PEREGRINE

    SBC: NOMOS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Computerized radiation therapy planning systems (RTP) are essential in Radiation Oncology for quantitative evaluation of radiation doses prior to patient treatment. Among currently available computational methods, the Monte Carlo method of calculating dose distributionsis most universal and accurate. It is believed that Monte Carlo software packages will become ...

    STTR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  2. ACSS2 inhibition in treating Alcohol Abuse

    SBC: EPIVARIO INC            Topic: 350

    Alcohol use disorder represents a tremendous burden on society. While our understanding of neuronal pathways and circuitry involved in addiction has grown of late, efficacy of available treatments has not seen the same success. We uncovered a novel epigenetic process controlling neuronal plasticity that is key to long-term memory formation, involving the metabolic enzyme ACSS21. ACSS2 generates ac ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. A Diarylheptanoid Scaffold to Treat Taopathies

    SBC: ALS BIOPHARMA, LLC            Topic: NIA

    DESCRIPTION: We identified the Myrica cerifera (Southern Bayberry) extract using a systematic screen as a potent reducer of the structural protein tau, which accumulates in a group of diseases called the tauopathies . The most prevalent tauopathy is Alzheimer's disease, for which there is renewed interest in the identification of tau- based therapeutic approaches to treat this devastating d ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Advancing Small Molecule Read Through Compounds to Prevent and/or Treat Heritable Pulmonary Artery Hypertension

    SBC: ADVENT THERAPEUTICS INC            Topic: NHLBI

    Advent Therapeutics is a company that develops new therapies for neonatal, pediatric, and Orphan Drug “niche” markets to address serious unmet medical needs. Our team proposes early stage development of a new treatment for hereditable pulmonary arterial hypertension (hPAH), a rare, hereditary disorder that involves progressive elevation of pulmonary arterial pressures, right heart failure, and ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. ALEXSA Adaptation for Use in Large Scale Substance Use Surveys

    SBC: ASSESSMENTS ILLUSTRATED            Topic: N/A

    DESCRIPTION (provided by applicant): This NIDA STTR reapplication is to develop a personal digital assistant (PDA) format of a validated child self- report (Assessment of Liability and EXposure to Substance use and Antisocial behavior(c) or ALEXSA(c)) for early harmful substance use, antisocial behavior, and risks for these behaviors. Large markets for this instrument include large-scale surveil ...

    STTR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  6. ALEXSA Standardization for Clinical Use

    SBC: ASSESSMENTS ILLUSTRATED            Topic: NIDA

    DESCRIPTION (provided by applicant): This STTR Phase II application is to finalize the one-of-its-kind Assessment of Liability and Exposure to Substance use and antisocial behavior(c) (ALEXSA(c)) for educator, pediatric, prevention and epidemiology uses. The ALEXSA system, first funded by a NIDA K-Award, acquires child-report (8- to 13-year-olds) data using an illustrated, computer format that is ...

    STTR Phase II 2012 Department of Health and Human ServicesNational Institutes of Health
  7. A Low-Cost Portable Multiplex Serum Molecular Test for HBV and HCV Detection

    SBC: LENIMA FIELD DIAGNOSTICS LLC            Topic: R

    DESCRIPTION provided by applicant Hepatitis B HB and hepatitis C HC are two of the most widespread infections worldwide caused by the blood borne HB virus HBV and HC virus HCV respectively About million and million people suffer from chronic HB CHB and chronic HC CHC respectively while about and people die each year due to the consequence of HB and ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. A Microfluidic/Nanofluidic System for Rapid Single Cell Proteomics

    SBC: FLUIDISPEC            Topic: 400

    Proteomics typically involves the analysis of the protein components of large populations of cells. Nearly all the of a cell’s machinery are proteins, so many diseases and responses to stimuli and stressors are manifested at the protein level. Proteomes are challenging to characterize fully for many reasons. Some of the key attributes of a proteome that make its characterization so challenging a ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. An Accessible Digital Intervention to Promote HIV Testing/Counseling and Prevention Among Adolescents

    SBC: Schell Games LLC            Topic: NICHD

    Abstract HIV disproportionately impacts minority adolescentsand most of them have neither undergone HIV testing and counselingHTCnor know their statusAdolescence is a "window of opportunity" to intervene with HIV behavior change interventionsChallenges to implementing and disseminating some effective HIV prevention programs in adolescents may limit their impactTo address these challengesinnovative ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. An additive solution to expand the lung transplant organ pool

    SBC: Peroxitech LLC            Topic: NHLBI

    PROJECT SUMMARY Major challenges in the field of lung transplantation are the low availability of healthy donor lungs (graft) and the damage to donor lungs post-transplant. These arise due to inflammation and oxidative damage initiated during the graft storage period. Among the multiple strategies employed to improve lung availability and transplant outcome are short storage times (comprising of a ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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