Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Mechanical generation of peri-valvular oscillatory flow to prevent deep venous thrombosis.

    SBC: OsciFlex LLC            Topic: NHLBI

    Project SummaryDeep venous thrombosisDVTand secondary pulmonary embolismPEaffectof the population and cause approximatelydeaths annually in the USImmobility and lack of muscular activity is the primary risk factor for DVTan effect attributed to reduced venous flowAutopsy studies have identified the venous valve sinus in the leg as the site of origin for DVTbut a molecular and cellular mechanism fo ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a tracheal sound sensor for early detection of hypoventilation due to opioid overdose.

    SBC: RTM Vital Signs, LLC            Topic: R41

    Abstract More thanAmericans died from drug overdose inand drug overdose is now the most common cause of death for people underyears old in the United StatesFurthermorethe number of overdose deaths is increasing with the rise of abuse of powerful synthetic opioidssuch as fentanylIn May ofNational Institutes of HealthNIHand National Institute on Drug AbuseNIDAdirectors DrsCollins and Volkow outlined ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Discovering a Small Molecule that Targets the KSHV Processivity Factor for Treating Oral and Systemic Kaposi Sarcoma

    SBC: Fox Chase Chemical Diversity Center, Inc.            Topic: NIDCR

    Kaposi SarcomaKSis the most common cancer in themillion worldwide AIDS populationKS tumors are caused by Kaposi Sarcoma Associated Herpes VirusKSHVEven though HAART therapy has resulted in a dramatic decline in KS in the USthis malignancy remains the most predominant tumor of AIDSParadoxicallyKS tumors arise in some AIDS patients following HAART treatmentdue to Immune Reconstitution Inflammatory S ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Serum Inflammasome proteins: Novel biomarker panel for radiation biodosimetry

    SBC: JT-Mesh Diagnostics LLC            Topic: NIEHS

    JT MeSh diagnostics is developing novel biodosimeter devices which will allow for rapidsimpleon site mass screening in the event of a nuclear disaster or an act of terrorismdirty bombBiodosimeters are critical in the event of a large scale radiological emergencyin the form of a nuclear disasterterrorist attack or radiation exposure of military personnelwhere a large population ofexposedindividuals ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Small-molecule combinationsexpand hematopoietic stem cell ex vivo and in vivo

    SBC: Advac Therapeutic LLC            Topic: NHLBI

    Small molecule combinations expand hematopoietic stem cell ex vivo and in vivo Abstract Hematopoietic stem cellsHSCsare featured by their self renewal potential and ability to differentiate into multiple blood lineagesHematopoietic stem cell transplantHSCTis a mainstay of life saving therapy for hematopoietic malignancies and hypoproliferative disordersThe use of noninvasively accessible umbilical ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a Personalized Bioreactor for Cell Culturing in Alginate Tubes

    SBC: CellGro Technologies, LLC            Topic: 400

    PROJECT SUMMARY ABSTRACT SignificanceCell therapy is expected to become an important method to treat chronic diseases such as diabetesrheumatoid arthritisretinal diseases like macular degeneration and certain types of cancersThe cell therapy market in general is projected to become a $billion industry byHuman pluripotent stem cellshPSCsare of particular importance since their utility as a source f ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. IND enabling development of LGM2605 as adjuvant treatment for asthma

    SBC: Lignamed, LLC            Topic: NIAID

    Project summary IND enabling development of LGMas adjuvant treatment for asthma Glucocorticoid resistance is a major treatment problem in asthmaOur recent studies in micenon human primates and severe asthma patientsalong with reports by others suggest that glucocorticoid receptorGRexpression was impaired by psychosocial stressin association with enhanced NF kB activation and glucocorticoid non res ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Associating Clinical Decision Support Use with Clinical Outcomes in a Visual Analytics Display

    SBC: PHRASE Health, INC.            Topic: NLM

    Project Summary Abstract Clinical decision supportCDSis a process for enhancing health related decisions and actions with pertinentorganized clinical knowledge and patient information to improve healthcare deliveryFor exampledoctors may have trouble remembering to order all guideline recommended care for sepsisCDS delivered via an order set in the electronic health recordEHRcan simplify this proce ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Minimally Invasive Intercostal Nerve Block Device to Treat Severe Pain and Reduce Usage of Opiates

    SBC: Thermaquil, Inc.            Topic: 106

    Project SummaryMost of thek Americans who undergo thoracotomy each year receive opiates to reduce postoperative pain because clinicians have few non addictivecost effective choices to control the severe pain patients often experience in the first two weeks after surgeryManaging pain post thoracotomy is critical to enable patients to take deep breaths and removevia coughinglung secretions that othe ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Production and quality analysis of clinical drug for a novel CNS protein kinase inhibitor therapeutic candidate

    SBC: NeuroKine Therapeutics, LLC            Topic: NIA

    ABSTRACT Alzheimer s diseaseADand related dementias are increasing rapidly yetremarkablythere are no approved disease modifying drugsVirtually all trials targeting amyloid related pathways have failed over the lastyearsRegrettablyfew alternative targets or pathways have been exploredThereforethere is an urgent need to explore alternative pathways as monotherapies or as constituents of a multi drug ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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