Award Data

DESCRIPTION (provided by applicant): About 3-4% of all fractures are estimated to be open fractures, where the fracture is exposed through defects in the skin and soft tissues. This equates to about 250,000 open fractures in the United States annually. Open fractures present a high risk of infection. Infection results in considerable financial burden to both the patient an healthcare system, requ ...

DESCRIPTION (provided by applicant): Due to its asymptomatic nature and lack of methods for early detection, gt 80% of pancreatic cancer (PC) patients present with an unresectable primary tumor with distant metastasis at the time of diagnosis. While the overall 5 year survival rate of pancreatic cancer is dismal, significantly better outcomes have been reported for smaller tumors detected at an e ...

DESCRIPTION (provided by applicant): This Phase I application aims at developing a generalizable electrochemical biosensing platform for detection of metal ions in water. Specifically, the main objective of the project is to validate the design of a convenient, cost-effective electrochemical ion (E-ION) sensing platform for direct detection of metal ion contaminants such as mercury (Hg2+), silver ...

DESCRIPTION (provided by applicant): Obstructive sleep apnea (OSA) is the most common type of sleep apnea. OSA affects an estimated 18-40 million adults and 0.7-3% of all children in the US. OSA results in tiredness, depression and fatigue, and has severalassociated common comorbidities. It is believed that over 80% of OSA remains undiagnosed. Poorer and disadvantaged communities are at higher ris ...

DESCRIPTION (provided by applicant): The US Centers for Disease Control and Prevention estimate that 1.6 - 3.8 million concussions occur annually. Although striking, these figures are vast underestimates of the actual number of afflicted individuals because many who have suffered a concussion are never diagnosed because they do not seek medical advice. During competition and practice, athletes are ...

DESCRIPTION provided by applicant The product is a slide coated with silica colloidal crystals to combine protein electrophoresis with matrix assisted laser desorption ionization mass spectrometry MALDI MS detection giving superior performance in both The Phase II proposal will be to develop an instrument for facile application of the slide in proteomics of intat glycoproteins This propos ...

DESCRIPTION provided by applicant This project aims to improve the accuracy of tests for early tooth decay dental caries specifically for interproximal surfaces where the posterior teeth abut one another In these regions there is no physical space to visually inspect or probe for caries Instead dentists rely on bitewing X rays BWs But dentists cannot tell whether lucencies observed ...

DESCRIPTION provided by applicant Advances in DNA sequencing technology have now made it practical and affordable to generate datasets containing millions of genetic attributes that can be tested for association with disease susceptibility The computational complexity of searching for genetic interactions over such high dimensional datasets imposes great challenges for genome wide associatio ...

DESCRIPTION provided by applicant Obstructive sleep disordered breathing OSDB is common in both children and adults and is recognized as having substantial health related consequences at all ages Laboratory polysomnography PSG is the gold standard for diagnosing OSDB but the procedure is not without problems Polysomnographic studies are complex invasive expensive not universally avail ...

DESCRIPTION provided by applicant The goal of this STTR Phase II collaboration between Purdue University and bioVidria Inc is to commercialize disruptive new technology for protein chromatography and then maximize its impact by serving the fastest growing segment of the pharmaceutical industry protein drugs The product is a reversed phase chromatography column that uses silica particles of ...