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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Particulate Composite Mixing Processes

    SBC: Global Engineering and Materials, Inc.            Topic: AF14AT22

    ABSTRACT: Global Engineering and Materials, Inc. (GEM) along with its team member Columbia University propose to develop a simulation tool for modeling mixing process of multi-particle composite systems and generating the ultimate microstructure. A combined theoretical, numerical, and experimental approach will be developed to create a high fidelity software product with a reduced order modeling ...

    STTR Phase I 2014 Department of DefenseAir Force
  2. Computational Model for Electrode Erosion by High-Pressure Moving Arcs

    SBC: CFD RESEARCH CORPORATION            Topic: AF11BT25

    ABSTRACT: The goal of this project is to develop theoretical models for electrode erosion in high-pressure arcs and incorporate them into computational tools for simulations of arc heaters. The complexity of the electrode material removal process is associated with the multi-phase nature of the arc-electrode interactions, melting and vaporization of the electrodes near the arc foot. Available mod ...

    STTR Phase II 2014 Department of DefenseAir Force
  3. A General-Purpose Software Tool for Multi-disciplinary Simulation Data Management and Learning

    SBC: CFD RESEARCH CORPORATION            Topic: AF11BT27

    ABSTRACT: The overall goal of the proposed effort is to develop and demonstrate a general-purpose, fast, and reliable management and learning software tool for analyzing massive data sets generated by dynamic multi-disciplinary simulation. In Phase I, key technology elements were developed and proof-of-principle was successfully demonstrated. Data management software encapsulating salient feature ...

    STTR Phase II 2014 Department of DefenseAir Force
  4. Non-ATP competitive inhibitors of cyclin dependent kinases as cancer therapeutics

    SBC: PPI PHARMACEUTICALS, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): As cancer is one of the leading causes of death in the United States with some sub-types remaining essentially untreatable, expansion of available drug targets will provide significant new options for the development ofmore effective antineoplastic agents. The major goal of this project is to apply a unique drug discovery strategy to cancer drug development. Th ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a Novel Antimicrobial Foley Catheter to Prevent CAUTIs

    SBC: HYDROMER, INC.            Topic: NIDDK

    DESCRIPTION (provided by applicant): Catheter-associated urinary tract infections (CAUTI) are a leading cause of hospital-acquired infections and lead to increased costs, suffering and mortality. A primary contributor to CAUTI is formation of bacterial biofilms on indwelling catheters. Biofilms are inherently resistant to most antibiotics, and once established serve as a bacterial reservoir propag ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. A Millimeter-wave Tunable Cavity for Ultra-sensitive Solids and Liquids DNP-NMR at Low Budget

    SBC: DOTY SCIENTIFIC, INC.            Topic: NIA

    ? DESCRIPTION (provided by applicant): NMR is probably the most powerful and widely used analytical technique for structure determination and function elucidation of molecules of all types, but it suffers from low sensitivity, particularly for insoluble biological macromolecules. Dynamic Nuclear Polarization (DNP) with Magic Angle Spinning (MAS) has recently demonstrated S/N gains exceeding t ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Use of EF2K Inhibitors to Reduce Toxicity to Normal Tissues in Chemotherapy

    SBC: LONGEVICA PHARMACEUTICALS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Eukaryotic elongation factor 2 protein kinase (eEF2K) is a ubiquitously expressed protein that belongs to a family of alpha kinases characterized by an atypical kinase domain. Our recent findings demonstrate that inhibition or genetic inactivation of eEF2K protects normal tissues from cytotoxic effects of chemotherapeutic agents and ionizing radiation. We hav ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Minimal piggyBac vectors for chromatin integration

    SBC: EXSCIEN CORPORATION            Topic: NIGMS

    In this grant, we describe novel transposon piggyBac vectors engineered to deliver transgenes as efficiently as currently available piggyBac systems, but with significantly less helper DNA co-delivered into the host genome. To generate these plasmids, we first identified an important and previously unreported aspect of transposon biology, that the full-length terminal domains required for successf ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Enhancing mtDNA Repair During Stroke Reperfusion to Reduce Brain Damage

    SBC: EXSCIEN CORPORATION            Topic: NINDS

    DESCRIPTION (provided by applicant): Attempts to develop drug treatments for acute stroke have not fulfilled expectations. Perhaps best illustrating this unsatisfactory situation is the hisory of therapeutic strategies directed at the inhibition of reactive oxygen species (ROS). While decades of laboratory and clinical studies make it clear that ROS are pathogenically important across the entire s ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  10. New Functionally-Graded Biohybrid Vascular Graft

    SBC: Vivo Biosciences Inc            Topic: NCATS

    DESCRIPTION (provided by applicant): In this Phase I STTR proposal, our RandD goal is the development and evaluation of a novel functionally-graded biohybrid vascular graft for small diameter (lt6 mm) coronary bypass applications. Tissue engineered vascular constructs developed to date have mostly utilized synthetic and animal- derived biomaterials and require pre-seeding of host cells before impl ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
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