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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Optimization of Cannabinoids for Development as FDA-Approved Migraine Therapeutics

    SBC: Schedule 1 Therapeutics, Inc.            Topic: NIDA

    Optimization of Cannabinoids for Development as FDA-Approved Migraine Therapeutics Project Summary: Migraine is a disorder that affects 15% of all people in the US, the majority of which are women. Migraine is one of the leading causes of missed days at work during which patients are unable to complete many daily activities. Currently approved treatments for migraine are not satisfying with at mos ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. A Novel DHA Treatment Approach for Alzheimer's Disease

    SBC: Orochem Technologies Inc.            Topic: NIA

    Alzheimer’s disease (AD) and related dementia (ADRD) are adversely impacting the healthy lifespan in our aging population. Fish oil has been suggested to improve AD/ADRD outcomes. The omega 3 fatty acids (Om3FA) in fish oil in particular DHA (docosahexaenoic acid) is a key molecule. Some data exists that DHA is beneficial for protection against age related cognitive decline and related dementia ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Step UP for STEM and Health Careers: An Intervention to Reduce STEM related biases towards young women and minorities

    SBC: RESILIENT GAMES STUDIO, LLC            Topic: NICHD

    Project Abstract The National Institutes of Health has a stated commitment to diversifying the national scientific workforce. While diversity has many dimensions, women and underrepresented minorities (i.e., black, Latinx, indigenous, and Pacific Islanders) are particularly underrepresented in Science, Technology, Engineering, and Mathematics (STEM) and health careers. Rather than ability, dispari ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Improving data capture in clinical research using a chatbot

    SBC: Dokbot, LLC            Topic: NLM

    PROJECT SUMMARY . Collecting complete and accurate outcome data directly from research participants is becoming increasingly important. Clinical researchers needs a cost-effective approach to capture high-quality patient-reported outcomes. Typically, data captured directly from participants is through self-administered questionnaires or through a human interviewer, each with their own advantages ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Correlative nonvital standard histopathology and vital multiphoton prehistopathology

    SBC: LiveBx, LLC            Topic: 400

    SUMMARY A common practice in medicine for handling freshly biopsied human tissue is to rapidly put it into a formalin solution. This “fixation” preserves the tissue from decay, allowing transportation to a (remote) pathology laboratory for standard histopathology or other biochemical/genetical analyses. However, formalin instantly “kills” the tissue, so that the biochemical and metabolic f ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Prevention of GVHD by a probiotic exopolysaccharide.

    SBC: HASENTECH            Topic: NIAID

    Abstract Graft versus host disease (GVHD) is an often lethal complication from allogeneic hematopoietic stem cell transplantation used as treatment for a variety of hematologic malignancies. GVHD results from an attack on host cells by alloreactive T cells of the donor. Standard prevention and treatment for GVHD is administration of broadly immunosuppressive drugs, which suppress alloreactive T ce ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Analysis of new compounds to treat familial hypercholesterolemia

    SBC: GRUTHAN BIOSCIENCE LLC            Topic: NHLBI

    PROJECT SUMMARY The long-term goal of the current proposal is to generate a new class of small molecules to treat familial hypercholesterolemia. Familial hypercholesterolemia (FH) patients suffer from excessively high levels of Low Density Lipoprotein Cholesterol (LDL-C), which if left untreated results in death from severe cardiovascular disease. FH is caused primarily by mutations in the LDL rec ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. MR Virtual Pathology of the Prostate

    SBC: QMIS            Topic: 102

    QMIS, LLC (Quantitative MRI Solutions) is developing a new MRI-based tool that reliably screens for prostate cancer (PCa). PCa is a leading cause of death (29,500 U.S. deaths in 2018). Current methods (PSA and digital rectal exam) are unreliable; they result in unnecessary biopsies while missing clinically significant PCa. MRI has potential to detect PCa at an early stage when it is highly curable ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Delivery of chemically modified PNA oligomers

    SBC: NUBAD, LLC            Topic: NIAID

    PROJECT SUMMARYRNA is a validated target for drug design, both as therapeutic and as a target. Targeting specific RNA, such as rRNA which are involved in proliferation and survival of bacteria is a promising approach. We are developing fast and low cost methods to screen sequence-specific small molecules for novel anti-ribosomal activities. We will construct sequence-specific chemically modified r ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Programming Metabolically Fit TILs for Immunotherapy

    SBC: Lipo-immuno Tech, LLC            Topic: NCI

    ABSTRACT Advances in molecular biology and genetic engineering have led to the design and use of modified T cells recognize tumors to achieve significant tumor control upon adoptive cell transfer (ACT) to patients. These T cells are either transduced with tumor antigen reactive T cell receptors (TCR), or chimeric antigen receptors (CARs). Recently, a surge in studies with neo-antigen reactive T ce ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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