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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Virtually Empowering Schools with Adolescent Immigrant Students (VISA-IS)

    SBC: Research, Evaluation and Social Solutions, Inc. (REESSI)            Topic: 102

    ABSTRACT VISA-IS/US GAMES The Issue: Many Hispanic youth face culturally related challenges such as discrimination, being perceived as a “threat” by White and Black Americans, having to juggle and reconcile their heritage and US cultural systems, and acculturation conflicts with parents. These cultural challenges are also related to schooling: in the US, school “success” is often defined i ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Improving data capture in clinical research using a chatbot

    SBC: Dokbot, LLC            Topic: NLM

    PROJECT SUMMARY . Collecting complete and accurate outcome data directly from research participants is becoming increasingly important. Clinical researchers needs a cost-effective approach to capture high-quality patient-reported outcomes. Typically, data captured directly from participants is through self-administered questionnaires or through a human interviewer, each with their own advantages ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Urbanscape: Single Shot Multi-Task 3D Reconstruction

    SBC: DZYNE Technologies Incorporated            Topic: DTRA18B001

    Hazard assessment tools that model the transport and dispersion of Chemical, Biological, Radiological, Nuclear and Explosive (CBRNE) materials through urban areas are only as good as the 3D models that inform the physics model. Maintaining accurate, up-to-date 3D models of urban areas is challenging. Even in the commercial world, urban construction and demolition may result in the models created a ...

    STTR Phase II 2020 Department of DefenseDefense Threat Reduction Agency
  4. Virtual Reality Tools to Enhance Evidence Based Treatment of Substance Use Disorders (R41/R42- Clinical Trial Optional)

    SBC: Brightline Interactive LLC            Topic: NIDA

    Randamp;R Other Project Information 7. Project Summary/Abstract Neurobiological changes caused by addiction impair behavioral control and increase relapse risk (Volkow, Koob, andamp; McLellan, 2016), substantiating the need for long-term care coordination and recovery engagement for individuals with Substance Use Disorders (SUD) (Humphreys, Malenka, Knutson, andamp; MacCoun, 2017). Because addicti ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Analysis of new compounds to treat familial hypercholesterolemia

    SBC: GRUTHAN BIOSCIENCE LLC            Topic: NHLBI

    PROJECT SUMMARY The long-term goal of the current proposal is to generate a new class of small molecules to treat familial hypercholesterolemia. Familial hypercholesterolemia (FH) patients suffer from excessively high levels of Low Density Lipoprotein Cholesterol (LDL-C), which if left untreated results in death from severe cardiovascular disease. FH is caused primarily by mutations in the LDL rec ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Inhibition of breast cancer cell metastases using a connexin43 mimetic peptide

    SBC: Acomhal Research, Inc.            Topic: 102

    PROJECT SUMMARY Breast cancer is one of the most diagnosed type of cancer and second leading cause of cancer-related death among women in the U.S. Treatment remains challenging due to the heterogeneity and highly dynamic nature of breast tumors. Although early detection through screening has largely contributed to a decline in breast cancer-related mortality, tumor recurrence and metastasis still ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Drone-Delivered Naloxone System for Opioid Overdose Treatment

    SBC: UAS ASSOCIATES LLC            Topic: NIDA

    Program Director/Principal Investigator (Last, First, Middle): Ornato, Joseph, Pasquale Summary One hundred thirty Americans die from an opioid overdose (OD) daily. The key to improving this survival is the timely delivery of the antidote naloxone. Current US Emergency Medical Services (EMS) systems are often unable to deliver the life-saving drug fast enough manner to save the victim’s life. Ou ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Delivery of chemically modified PNA oligomers

    SBC: NUBAD, LLC            Topic: NIAID

    PROJECT SUMMARYRNA is a validated target for drug design, both as therapeutic and as a target. Targeting specific RNA, such as rRNA which are involved in proliferation and survival of bacteria is a promising approach. We are developing fast and low cost methods to screen sequence-specific small molecules for novel anti-ribosomal activities. We will construct sequence-specific chemically modified r ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Programming Metabolically Fit TILs for Immunotherapy

    SBC: Lipo-immuno Tech, LLC            Topic: NCI

    ABSTRACT Advances in molecular biology and genetic engineering have led to the design and use of modified T cells recognize tumors to achieve significant tumor control upon adoptive cell transfer (ACT) to patients. These T cells are either transduced with tumor antigen reactive T cell receptors (TCR), or chimeric antigen receptors (CARs). Recently, a surge in studies with neo-antigen reactive T ce ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. BEST-OUD: Behavioral Economic Screening Tool of Opioid Use Disorder for use in clinical practice

    SBC: BEAM Diagnostics, Inc.            Topic: 41

    PROJECT SUMMARY Fatal overdose from opioid misuse is one of the most pressing issues affecting the modern worldAs one of the nation s leading preventable causes of deatha critical line of defense against opioid use disorderOUDmust be standardized screening provided by the patient s primary care physicianpsychiatristand or counselorStandardized screening methods for opioidshoweverare simply inferio ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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