Award Data

This proposal suggests research on security issues for mobile databases running on a mobile ad hoc network (MANET). It will explore both state of the art commercial systems and advanced research issues for mobile security management. The first step will involve an extensive study of the commercial off-the-shelf technology. This study will identify the resources that can be used for addressing secu ...

One of the most significant challenges facing the Defense Industry today is the lack of interoperability between software applications. Weapons systems data is voluminous, complex, and distributed across many disparate applications. Typically, only a few of these applications are truly integrated and manual processes are required to synchronize data maintained across multiple systems. Users mus ...

Mass spectrometry is a technology with wide-ranging applications in defense and homeland security. The technique is widely applicable and exceedingly sensitive, but for many molecules there can be ambiguities regarding the isomeric and conformeric form. As the number of atoms in a molecule increases, the number of stable isomers raises dramatically. Recent research has shown that the binding en ...

This proposal focuses on developing a protein manufacturing platform based on a novel vector system that can rapidly and efficiently generate cell lines capable of producing proteins at high yield and purity in a short time period. Lentigen is able to perform such a quick protein manufacturing process based on its LentiMaxT lentiviral (LV) gene delivery technology that stably delivers one or more ...

The Phase I objective is to demonstrate dislocation reduction in both cadmium telluride (CdTe) and subsequent HgCdTe epitaxial layers grown on silicon substrate using an intermediate nanocrystalline CdTe buffer layer of optimized thickness and size. Nanocrystalline CdTe buffer layer will be deposited on silicon substrate by low cost processing method/s. The method consists of (a) Colloidal synthe ...

Sensor Electronic Technology, Inc. proposes to use QD-like fluctuations of InGaN QW with controllable spatial distribution for high efficiency green LEDs. We will investigate both theoretically and experimentally the performance of green InGaN MQW structures with fluctuations of composition and thickness of InGaN quantum wells. Both types of these fluctuations would lead to the spatial localizatio ...

DESCRIPTION (provided by applicant): One of the largest bottlenecks in high-throughput protein structure determination (structural genomics) and in subsequent drug targeting (pharmocogenomics) is the acquisition of soluble correctly folded functional protein products. Unfortunately, a large amount of the protein expression systems that are commonly used yield insoluble or soluble misfolded protein ...

DESCRIPTION (provided by applicant): One of the primary and disabling clinical manifestations of Parkinson's disease (PD) is locomotor dysfunction, such as small, variable stride length and freezing of gait. Treatment of PD to a large extent focuses on replacing depleted dopamine at the striatum to maintain mobility for as long as possible. Clinical assessment relies on brief observation and frequ ...

DESCRIPTION (provided by applicant): It is anticipated that only a third of today's high school students will go onto college despite consistent data that support the benefit of post-secondary education for individuals. Concurrently, daily Internet use among adolescents is nearing the fifty-percent mark, with broadband Internet steadily growing toward ubiquity. This project aims to leverage the ma ...

DESCRIPTION (provided by applicant): Our long term goal is to develop cellular based immunotherapy for the treatment of malignancy. One approach to enhancing the effects of cellular immunotherapy is via gene therapy. We are currently focused on enhancing the antitumor effects of adoptive T cell therapy using lentiviral vector-mediated genetic modification of cells to express a universal T cell rec ...